View in EDS

Outcome and cost‐effectiveness of transdiagnostic cognitive behavioral therapy compared with management as usual for youth with common mental health problems: Long‐term results from the Mind‐My‐Mind randomized trial.

Saved in:
Bibliographic Details
Title: Outcome and cost‐effectiveness of transdiagnostic cognitive behavioral therapy compared with management as usual for youth with common mental health problems: Long‐term results from the Mind‐My‐Mind randomized trial.
Authors: Vassard, Ditte (AUTHOR), Rimvall, Martin Køster (AUTHOR), Wolf, Rasmus Trap (AUTHOR), Christensen, Robin (AUTHOR), Nielsen, Sabrina M. (AUTHOR), Plessen, Kerstin Jessica (AUTHOR), Verhulst, Frank (AUTHOR), Bilenberg, Niels (AUTHOR), Thomsen, Per Hove (AUTHOR), Thastum, Mikael (AUTHOR), Neumer, Simon‐Peter (AUTHOR), Pagsberg, Anne Katrine (AUTHOR), Silverman, Wendy K. (AUTHOR), Correll, Christoph U. (AUTHOR), Jeppesen, Pia (AUTHOR)
Source: Journal of Child Psychology & Psychiatry. Aug2026, Vol. 67 Issue 8, p1307-1320. 14p.
Subjects: Mental illness treatment, Psychotherapy, Quality-adjusted life years, Cost effectiveness, Research funding, Health status indicators, Statistical sampling, Questionnaires, Logistic regression analysis, Treatment effectiveness, Randomized controlled trials, Descriptive statistics, Longitudinal method, Odds ratio, Behavior disorders in children, Quality of life, Cognitive therapy, Confidence intervals, Health outcome assessment, Data analysis software, Anxiety disorders, Proportional hazards models, Sensitivity & specificity (Statistics), Mental depression, Medical care costs, Evaluation, Adolescence, Children
Geographic Terms: Germany
Abstract: Background: Credible long‐term outcomes from randomized trials evaluating the effectiveness and cost‐effectiveness of preventive programs for mental health problems are needed. We compared long‐term effects of the Mind My Mind (MMM) transdiagnostic cognitive behavioral therapy (CBT) program to management as usual (MAU). Methods: The study was a pragmatic, multisite, randomized superiority trial (2017–2019) involving youths aged 6–16 years with anxiety, depressive symptoms, and/or behavioral disturbances, recruited through family self‐referral. The MMM intervention included 9–13 weekly CBT sessions. The primary outcome was change from baseline in parent‐reported impact of mental health problems at 3‐year follow‐up post‐randomization using the Strengths and Difficulties Questionnaire (SDQ) impact scale. Register‐based outcomes tracked youths' psychiatric diagnoses in mental health services. To assess cost‐effectiveness, we calculated the incremental costs and incremental quality‐adjusted life years (QALYs). All primary analyses followed the intention‐to‐treat (ITT) approach. Clinical trials registration: ID NCT04804917. Results: Among 396 youths randomized (baseline mean [SD] age, 10.3 [2.4] years; 52.0% boys; MMM n = 197, MAU n = 199), the 3‐year follow‐up (median 167 weeks; range 124–203 weeks) primary outcome data were available in 69.0% and 59.3%, respectively. The decrease in SDQ‐impact‐score from baseline to 3‐year follow‐up (4.12→1.79 points [MMM] and 4.21→1.85 [MAU]) was similar (between‐group difference, 0.06 [95% CI −0.41 to 0.52]; p =.81). An equal proportion (25%) of youths in MMM and MAU were diagnosed with any mental disorder during follow‐up (HR 1.01, 95% CI 0.68–1.50). Total costs over the intervention period were higher in the MMM group (incremental costs 3,014 Euros [95% CI: 2.174–3.855]). Cost‐effectiveness analyses favored MMM: QALY net gain 0.121 (95% CI 0.045–0.196); the cost‐effectiveness ratio was 24,789 Euro/QALY. Conclusions: Although MMM was potentially cost‐effective, the beneficial effects diminished over 3 years post‐treatment. The findings highlight the need for strategies to sustain long‐term effects. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Child Psychology & Psychiatry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 195154925
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Outcome and cost‐effectiveness of transdiagnostic cognitive behavioral therapy compared with management as usual for youth with common mental health problems: Long‐term results from the Mind‐My‐Mind randomized trial.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Vassard%2C+Ditte%22">Vassard, Ditte</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rimvall%2C+Martin+Køster%22">Rimvall, Martin Køster</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wolf%2C+Rasmus+Trap%22">Wolf, Rasmus Trap</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Christensen%2C+Robin%22">Christensen, Robin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nielsen%2C+Sabrina+M%2E%22">Nielsen, Sabrina M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Plessen%2C+Kerstin+Jessica%22">Plessen, Kerstin Jessica</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Verhulst%2C+Frank%22">Verhulst, Frank</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bilenberg%2C+Niels%22">Bilenberg, Niels</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Thomsen%2C+Per+Hove%22">Thomsen, Per Hove</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Thastum%2C+Mikael%22">Thastum, Mikael</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Neumer%2C+Simon‐Peter%22">Neumer, Simon‐Peter</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pagsberg%2C+Anne+Katrine%22">Pagsberg, Anne Katrine</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Silverman%2C+Wendy+K%2E%22">Silverman, Wendy K.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Correll%2C+Christoph+U%2E%22">Correll, Christoph U.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jeppesen%2C+Pia%22">Jeppesen, Pia</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Journal+of+Child+Psychology+%26+Psychiatry%22">Journal of Child Psychology & Psychiatry</searchLink>. Aug2026, Vol. 67 Issue 8, p1307-1320. 14p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Mental+illness+treatment%22">Mental illness treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Psychotherapy%22">Psychotherapy</searchLink><br /><searchLink fieldCode="DE" term="%22Quality-adjusted+life+years%22">Quality-adjusted life years</searchLink><br /><searchLink fieldCode="DE" term="%22Cost+effectiveness%22">Cost effectiveness</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Health+status+indicators%22">Health status indicators</searchLink><br /><searchLink fieldCode="DE" term="%22Statistical+sampling%22">Statistical sampling</searchLink><br /><searchLink fieldCode="DE" term="%22Questionnaires%22">Questionnaires</searchLink><br /><searchLink fieldCode="DE" term="%22Logistic+regression+analysis%22">Logistic regression analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+effectiveness%22">Treatment effectiveness</searchLink><br /><searchLink fieldCode="DE" term="%22Randomized+controlled+trials%22">Randomized controlled trials</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Longitudinal+method%22">Longitudinal method</searchLink><br /><searchLink fieldCode="DE" term="%22Odds+ratio%22">Odds ratio</searchLink><br /><searchLink fieldCode="DE" term="%22Behavior+disorders+in+children%22">Behavior disorders in children</searchLink><br /><searchLink fieldCode="DE" term="%22Quality+of+life%22">Quality of life</searchLink><br /><searchLink fieldCode="DE" term="%22Cognitive+therapy%22">Cognitive therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Confidence+intervals%22">Confidence intervals</searchLink><br /><searchLink fieldCode="DE" term="%22Health+outcome+assessment%22">Health outcome assessment</searchLink><br /><searchLink fieldCode="DE" term="%22Data+analysis+software%22">Data analysis software</searchLink><br /><searchLink fieldCode="DE" term="%22Anxiety+disorders%22">Anxiety disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Proportional+hazards+models%22">Proportional hazards models</searchLink><br /><searchLink fieldCode="DE" term="%22Sensitivity+%26+specificity+%28Statistics%29%22">Sensitivity & specificity (Statistics)</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+care+costs%22">Medical care costs</searchLink><br /><searchLink fieldCode="DE" term="%22Evaluation%22">Evaluation</searchLink><br /><searchLink fieldCode="DE" term="%22Adolescence%22">Adolescence</searchLink><br /><searchLink fieldCode="DE" term="%22Children%22">Children</searchLink>
– Name: SubjectGeographic
  Label: Geographic Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Germany%22">Germany</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: Credible long‐term outcomes from randomized trials evaluating the effectiveness and cost‐effectiveness of preventive programs for mental health problems are needed. We compared long‐term effects of the Mind My Mind (MMM) transdiagnostic cognitive behavioral therapy (CBT) program to management as usual (MAU). Methods: The study was a pragmatic, multisite, randomized superiority trial (2017–2019) involving youths aged 6–16 years with anxiety, depressive symptoms, and/or behavioral disturbances, recruited through family self‐referral. The MMM intervention included 9–13 weekly CBT sessions. The primary outcome was change from baseline in parent‐reported impact of mental health problems at 3‐year follow‐up post‐randomization using the Strengths and Difficulties Questionnaire (SDQ) impact scale. Register‐based outcomes tracked youths' psychiatric diagnoses in mental health services. To assess cost‐effectiveness, we calculated the incremental costs and incremental quality‐adjusted life years (QALYs). All primary analyses followed the intention‐to‐treat (ITT) approach. Clinical trials registration: ID NCT04804917. Results: Among 396 youths randomized (baseline mean [SD] age, 10.3 [2.4] years; 52.0% boys; MMM n = 197, MAU n = 199), the 3‐year follow‐up (median 167 weeks; range 124–203 weeks) primary outcome data were available in 69.0% and 59.3%, respectively. The decrease in SDQ‐impact‐score from baseline to 3‐year follow‐up (4.12→1.79 points [MMM] and 4.21→1.85 [MAU]) was similar (between‐group difference, 0.06 [95% CI −0.41 to 0.52]; p =.81). An equal proportion (25%) of youths in MMM and MAU were diagnosed with any mental disorder during follow‐up (HR 1.01, 95% CI 0.68–1.50). Total costs over the intervention period were higher in the MMM group (incremental costs 3,014 Euros [95% CI: 2.174–3.855]). Cost‐effectiveness analyses favored MMM: QALY net gain 0.121 (95% CI 0.045–0.196); the cost‐effectiveness ratio was 24,789 Euro/QALY. Conclusions: Although MMM was potentially cost‐effective, the beneficial effects diminished over 3 years post‐treatment. The findings highlight the need for strategies to sustain long‐term effects. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Child Psychology & Psychiatry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=195154925
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/jcpp.70128
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 14
        StartPage: 1307
    Subjects:
      – SubjectFull: Mental illness treatment
        Type: general
      – SubjectFull: Psychotherapy
        Type: general
      – SubjectFull: Quality-adjusted life years
        Type: general
      – SubjectFull: Cost effectiveness
        Type: general
      – SubjectFull: Research funding
        Type: general
      – SubjectFull: Health status indicators
        Type: general
      – SubjectFull: Statistical sampling
        Type: general
      – SubjectFull: Questionnaires
        Type: general
      – SubjectFull: Logistic regression analysis
        Type: general
      – SubjectFull: Treatment effectiveness
        Type: general
      – SubjectFull: Randomized controlled trials
        Type: general
      – SubjectFull: Descriptive statistics
        Type: general
      – SubjectFull: Longitudinal method
        Type: general
      – SubjectFull: Odds ratio
        Type: general
      – SubjectFull: Behavior disorders in children
        Type: general
      – SubjectFull: Quality of life
        Type: general
      – SubjectFull: Cognitive therapy
        Type: general
      – SubjectFull: Confidence intervals
        Type: general
      – SubjectFull: Health outcome assessment
        Type: general
      – SubjectFull: Data analysis software
        Type: general
      – SubjectFull: Anxiety disorders
        Type: general
      – SubjectFull: Proportional hazards models
        Type: general
      – SubjectFull: Sensitivity & specificity (Statistics)
        Type: general
      – SubjectFull: Mental depression
        Type: general
      – SubjectFull: Medical care costs
        Type: general
      – SubjectFull: Evaluation
        Type: general
      – SubjectFull: Adolescence
        Type: general
      – SubjectFull: Children
        Type: general
      – SubjectFull: Germany
        Type: general
    Titles:
      – TitleFull: Outcome and cost‐effectiveness of transdiagnostic cognitive behavioral therapy compared with management as usual for youth with common mental health problems: Long‐term results from the Mind‐My‐Mind randomized trial.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Vassard, Ditte
      – PersonEntity:
          Name:
            NameFull: Rimvall, Martin Køster
      – PersonEntity:
          Name:
            NameFull: Wolf, Rasmus Trap
      – PersonEntity:
          Name:
            NameFull: Christensen, Robin
      – PersonEntity:
          Name:
            NameFull: Nielsen, Sabrina M.
      – PersonEntity:
          Name:
            NameFull: Plessen, Kerstin Jessica
      – PersonEntity:
          Name:
            NameFull: Verhulst, Frank
      – PersonEntity:
          Name:
            NameFull: Bilenberg, Niels
      – PersonEntity:
          Name:
            NameFull: Thomsen, Per Hove
      – PersonEntity:
          Name:
            NameFull: Thastum, Mikael
      – PersonEntity:
          Name:
            NameFull: Neumer, Simon‐Peter
      – PersonEntity:
          Name:
            NameFull: Pagsberg, Anne Katrine
      – PersonEntity:
          Name:
            NameFull: Silverman, Wendy K.
      – PersonEntity:
          Name:
            NameFull: Correll, Christoph U.
      – PersonEntity:
          Name:
            NameFull: Jeppesen, Pia
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 08
              Text: Aug2026
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-print
              Value: 00219630
          Numbering:
            – Type: volume
              Value: 67
            – Type: issue
              Value: 8
          Titles:
            – TitleFull: Journal of Child Psychology & Psychiatry
              Type: main
ResultId 1