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Evaluating the efficacy of placenta extract gel in wound healing as an adjunct treatment in minor periodontal surgical procedures: A clinical study.

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Title: Evaluating the efficacy of placenta extract gel in wound healing as an adjunct treatment in minor periodontal surgical procedures: A clinical study.
Authors: Greeshma, Patnam (AUTHOR), Prasanna, Jammula Surya (AUTHOR), Gahana, Ring (AUTHOR)
Source: Journal of Oral Research & Review. Jul-Dec2026, Vol. 18 Issue 2, p190-198. 9p.
Subjects: Wound healing, Gingiva surgery, Regeneration (Biology), Clinical trials, Anti-inflammatory agents, Pain management, Tissue extracts
Abstract: Context: Human placental extract functions as a biogenic stimulator and possesses important immunotropic, anti-inflammatory, and tissue-regenerative properties. It is known for its capability to modulate both cellular and humoral immunity, which assists in the healing process, especially in chronic, slow-healing wounds, and inflammatory conditions. Aims: To evaluate the clinical effectiveness of topical Placentrex gel in enhancing wound healing compared to the natural healing process after minor periodontal surgical procedures. Settings and Design: Randomized, single-blind clinical trial. Materials and Methods: This was a randomized, single-blind clinical trial. Twenty healthy patients aged between 20 and 50 years, who required minor periodontal surgeries, were randomly divided into two groups. Group A consisted of 10 patients who received Placentrex gel, whereas Group B had 10 patients in the control group. In both groups, postoperative medications were prescribed. Statistical Analysis Used: The outcomes measured included the Landry, Turnbull, and Howley Healing Index (HI), as well as the Visual Analog Scale (VAS) for pain, assessed at 1 week, 2 weeks, and 1-month postsurgery. Mann–Whitney U test, Fisher's exact test, Wilcoxon signed-rank test, and Kruskal–Wallis test were used for statistical evaluation. Results: The HI scores were significantly higher in the Placentrex group at both 1 week (3.40 ± 0.52 vs. 2.80 ± 0.42; P = 0.017) and 2 weeks (4.00 ± 0.00 vs. 3.30 ± 0.48; P = 0.002). Although VAS scores were lower in Group A at all time points, the differences between the groups were not statistically significant: week 1 (P = 0.128), week 2 (P = 0.151), and 1 month (P = 0.168). Conclusions: Topical Placentrex gel demonstrated earlier signs of improved wound healing after minor periodontal procedures, along with a trend of reduced pain. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Oral Research & Review is the property of Wolters Kluwer India Pvt Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Evaluating the efficacy of placenta extract gel in wound healing as an adjunct treatment in minor periodontal surgical procedures: A clinical study.
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  Data: <searchLink fieldCode="AR" term="%22Greeshma%2C+Patnam%22">Greeshma, Patnam</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Prasanna%2C+Jammula+Surya%22">Prasanna, Jammula Surya</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gahana%2C+Ring%22">Gahana, Ring</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Oral+Research+%26+Review%22">Journal of Oral Research & Review</searchLink>. Jul-Dec2026, Vol. 18 Issue 2, p190-198. 9p.
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  Data: <searchLink fieldCode="DE" term="%22Wound+healing%22">Wound healing</searchLink><br /><searchLink fieldCode="DE" term="%22Gingiva+surgery%22">Gingiva surgery</searchLink><br /><searchLink fieldCode="DE" term="%22Regeneration+%28Biology%29%22">Regeneration (Biology)</searchLink><br /><searchLink fieldCode="DE" term="%22Clinical+trials%22">Clinical trials</searchLink><br /><searchLink fieldCode="DE" term="%22Anti-inflammatory+agents%22">Anti-inflammatory agents</searchLink><br /><searchLink fieldCode="DE" term="%22Pain+management%22">Pain management</searchLink><br /><searchLink fieldCode="DE" term="%22Tissue+extracts%22">Tissue extracts</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Context: Human placental extract functions as a biogenic stimulator and possesses important immunotropic, anti-inflammatory, and tissue-regenerative properties. It is known for its capability to modulate both cellular and humoral immunity, which assists in the healing process, especially in chronic, slow-healing wounds, and inflammatory conditions. Aims: To evaluate the clinical effectiveness of topical Placentrex gel in enhancing wound healing compared to the natural healing process after minor periodontal surgical procedures. Settings and Design: Randomized, single-blind clinical trial. Materials and Methods: This was a randomized, single-blind clinical trial. Twenty healthy patients aged between 20 and 50 years, who required minor periodontal surgeries, were randomly divided into two groups. Group A consisted of 10 patients who received Placentrex gel, whereas Group B had 10 patients in the control group. In both groups, postoperative medications were prescribed. Statistical Analysis Used: The outcomes measured included the Landry, Turnbull, and Howley Healing Index (HI), as well as the Visual Analog Scale (VAS) for pain, assessed at 1 week, 2 weeks, and 1-month postsurgery. Mann–Whitney U test, Fisher's exact test, Wilcoxon signed-rank test, and Kruskal–Wallis test were used for statistical evaluation. Results: The HI scores were significantly higher in the Placentrex group at both 1 week (3.40 ± 0.52 vs. 2.80 ± 0.42; P = 0.017) and 2 weeks (4.00 ± 0.00 vs. 3.30 ± 0.48; P = 0.002). Although VAS scores were lower in Group A at all time points, the differences between the groups were not statistically significant: week 1 (P = 0.128), week 2 (P = 0.151), and 1 month (P = 0.168). Conclusions: Topical Placentrex gel demonstrated earlier signs of improved wound healing after minor periodontal procedures, along with a trend of reduced pain. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Oral Research & Review is the property of Wolters Kluwer India Pvt Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.4103/jorr.jorr_98_26
    Languages:
      – Code: eng
        Text: English
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        PageCount: 9
        StartPage: 190
    Subjects:
      – SubjectFull: Wound healing
        Type: general
      – SubjectFull: Gingiva surgery
        Type: general
      – SubjectFull: Regeneration (Biology)
        Type: general
      – SubjectFull: Clinical trials
        Type: general
      – SubjectFull: Anti-inflammatory agents
        Type: general
      – SubjectFull: Pain management
        Type: general
      – SubjectFull: Tissue extracts
        Type: general
    Titles:
      – TitleFull: Evaluating the efficacy of placenta extract gel in wound healing as an adjunct treatment in minor periodontal surgical procedures: A clinical study.
        Type: main
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          Name:
            NameFull: Greeshma, Patnam
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            NameFull: Prasanna, Jammula Surya
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          Name:
            NameFull: Gahana, Ring
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          Dates:
            – D: 01
              M: 07
              Text: Jul-Dec2026
              Type: published
              Y: 2026
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            – TitleFull: Journal of Oral Research & Review
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