Bibliographic Details
| Title: |
Hippocampal glutamate concentration predicts cerebral theta oscillations during cognitive processing. |
| Authors: |
Gallinat, J., Kunz, D., Senkowski, D., Kienast, T., Seifert, F., Schubert, F., Heinz, A. |
| Source: |
Psychopharmacology. Jul2006, Vol. 187 Issue 1, p103-111. 9p. 1 Black and White Photograph, 5 Graphs. |
| Subjects: |
Neurons, Neural transmission, Human information processing, Glutamine, Prefrontal cortex |
| Abstract: |
Rationale: Brain waves reflect collective behavior of neurons and provide insight into distributed network processing. Frontal and hippocampal theta oscillations (4-7 Hz) were linked to cognitive tasks and animal studies have suggested an involvement of glutamatergic neurotransmission in integrative frontal-hippocampal processing. Human evidence for such relationships is lacking. Methods: Here, we studied the associations between glutamate concentrations in the hippocampal region, measured by a 3-T proton magnetic resonance spectroscopy (1H-MRS), and EEG theta activity during an auditory target detection paradigm. Results: A robust relationship between hippocampal glutamate and frontal theta activity during stimulus processing was found. Moreover, frontal theta oscillations were related to response speed. Conclusion: The results suggest a functional coupling between the frontal cortex and hippocampal region during stimulus processing and support the idea of the hippocampus as a neural rhythm generator driven by glutamatergic neurotransmission. These preliminary data show, for the first time, a relationship between in vivo measured glutamate and basic cerebral information processing in humans. [ABSTRACT FROM AUTHOR] |
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| Database: |
Psychology and Behavioral Sciences Collection |
