Bibliographic Details
| Title: |
Hyperserotoninemia and Altered Immunity in Autism. |
| Authors: |
Burgess, Nancy K., Sweeten, Thayne L., McMahon, William M., Fujinami, Robert S. |
| Source: |
Journal of Autism & Developmental Disorders. Oct2006, Vol. 36 Issue 5, p697-704. 8p. 1 Chart. |
| Subjects: |
Autism, Developmental disabilities, Serotonin, Immunological adjuvants, Neuropsychiatry, Immunologic diseases, Autoantibodies, Immune system, Blood testing |
| Abstract: |
One of the most consistent biological findings in autism is elevated whole blood serotonin (5-HT) levels found in about 1/3 of cases. Immune abnormalities are also commonly observed in this disorder. Given 5-HT’s role as an immunomodulator, possible connections between 5-HT and immune abnormalities in autism are explored in this review. Areas of focus include hyperserotoninemia and cellular immune function, autoantibodies to 5-HT receptors, and 5-HT’s role in autoimmunity. Further research is needed to determine the interactions between neuropsychiatric and immune dysfunction in autism and related disorders. [ABSTRACT FROM AUTHOR] |
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| Database: |
Psychology and Behavioral Sciences Collection |
