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Reciprocal TH17 and Regulatory T Cell Differentiation Mediated by Retinoic Acid.

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Title: Reciprocal TH17 and Regulatory T Cell Differentiation Mediated by Retinoic Acid.
Authors: Mucida, Daniel, Park, Yunji, Kim, Gisen, Turovskaya, Olga, Scott, Lain, Kronenberg, Mitchell, Cheroutre, Hilde
Source: Science (pre-March 2025). 7/13/2007, Vol. 317 Issue 5835, p256-260. 5p. 4 Graphs.
Subjects: Autoimmunity -- Molecular aspects, Immunogenetics, T cell differentiation, Cytokinesis, Interleukin-6, Suppressor cells, Vitamin A, Tretinoin, Gynecologic pathology
Abstract: The cytokine transforming growth factor-β (TGF-β) converts naïve T cells into regulatory T (Treg) cells that prevent autoimmunity. However, in the presence of interleukin-6 (IL-6), TGF-β has also been found to promote the differentiation of naïve T lymphocytes into proinflammatory IL-17 cytokine-producing I helper 17 (TH17) cells, which promote autoimmunity and inflammation. This raises the question of how TGF-β can generate such distinct outcomes. We identified the vitamin A metabolite retinoic acid as a key regulator of TGF-β-dependent immune responses, capable of inhibiting the IL-6-driven induction of proinflammatory TH17 cells and promoting anti- inflammatory Treg cell differentiation. These findings indicate that a common metabolite can regulate the balance between pro- and anti-inflammatory immunity. [ABSTRACT FROM AUTHOR]
Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Reciprocal T<subscript>H</subscript>17 and Regulatory T Cell Differentiation Mediated by Retinoic Acid.
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  Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 7/13/2007, Vol. 317 Issue 5835, p256-260. 5p. 4 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Autoimmunity+--+Molecular+aspects%22">Autoimmunity -- Molecular aspects</searchLink><br /><searchLink fieldCode="DE" term="%22Immunogenetics%22">Immunogenetics</searchLink><br /><searchLink fieldCode="DE" term="%22T+cell+differentiation%22">T cell differentiation</searchLink><br /><searchLink fieldCode="DE" term="%22Cytokinesis%22">Cytokinesis</searchLink><br /><searchLink fieldCode="DE" term="%22Interleukin-6%22">Interleukin-6</searchLink><br /><searchLink fieldCode="DE" term="%22Suppressor+cells%22">Suppressor cells</searchLink><br /><searchLink fieldCode="DE" term="%22Vitamin+A%22">Vitamin A</searchLink><br /><searchLink fieldCode="DE" term="%22Tretinoin%22">Tretinoin</searchLink><br /><searchLink fieldCode="DE" term="%22Gynecologic+pathology%22">Gynecologic pathology</searchLink>
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  Data: The cytokine transforming growth factor-β (TGF-β) converts naïve T cells into regulatory T (Treg) cells that prevent autoimmunity. However, in the presence of interleukin-6 (IL-6), TGF-β has also been found to promote the differentiation of naïve T lymphocytes into proinflammatory IL-17 cytokine-producing I helper 17 (TH17) cells, which promote autoimmunity and inflammation. This raises the question of how TGF-β can generate such distinct outcomes. We identified the vitamin A metabolite retinoic acid as a key regulator of TGF-β-dependent immune responses, capable of inhibiting the IL-6-driven induction of proinflammatory TH17 cells and promoting anti- inflammatory Treg cell differentiation. These findings indicate that a common metabolite can regulate the balance between pro- and anti-inflammatory immunity. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=25917626
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        Value: 10.1126/science.1145697
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        Text: English
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        PageCount: 5
        StartPage: 256
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      – SubjectFull: Autoimmunity -- Molecular aspects
        Type: general
      – SubjectFull: Immunogenetics
        Type: general
      – SubjectFull: T cell differentiation
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      – SubjectFull: Cytokinesis
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      – SubjectFull: Interleukin-6
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      – SubjectFull: Suppressor cells
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      – SubjectFull: Vitamin A
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      – SubjectFull: Tretinoin
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      – SubjectFull: Gynecologic pathology
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      – TitleFull: Reciprocal TH17 and Regulatory T Cell Differentiation Mediated by Retinoic Acid.
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              M: 07
              Text: 7/13/2007
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              Y: 2007
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              Value: 317
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