Bibliographic Details
| Title: |
Serotonin transporter binding after recovery from eating disorders. |
| Authors: |
Bailer, Ursula F., Frank, Guido K., Henry, Shannan E., Price, Julie C., Meltzer, Carolyn C., Becker, Carl, Ziolko, Scott K., Mathis, Chester A., Wagner, Angela, Barbarich-Marsteller, Nicole C., Putnam, Karen, Kaye, Walter H. |
| Source: |
Psychopharmacology. Dec2007, Vol. 195 Issue 3, p315-324. 10p. 1 Color Photograph, 2 Charts, 2 Graphs. |
| Subjects: |
Serotonin, Biological transport, Anorexia nervosa, Bulimia, Menstrual cycle, Eating disorders |
| Abstract: |
Several lines of evidence suggest that altered serotonin (5-HT) function persists after recovery from anorexia nervosa (AN) and bulimia nervosa (BN). We compared 11 subjects who recovered (>1 year normal weight, regular menstrual cycles, no bingeing or purging) from restricting-type AN (REC RAN), 7 who recovered from bulimia-type AN (REC BAN), 9 who recovered from BN (REC BN), and 10 healthy control women (CW). Positron emission tomography (PET) imaging with [11C]McN5652 was used to assess the 5-HT transporter (5-HTT). For [11C]McN5652, distribution volume (DV) values were determined using a two-compartment, three-parameter tracer kinetic model, and specific binding was assessed using the binding potential (BP, BP = DVregion of interest/DVcerebellum − 1). After correction for multiple comparisons, the four groups showed significant ( p < 0.05) differences for [11C]McN5652 BP values for the dorsal raphe and antero-ventral striatum (AVS). Post-hoc analysis revealed that REC RAN had significantly increased [11C]McN5652 BP compared to REC BAN in these regions. Divergent 5-HTT activity in subtypes of eating disorder subjects may provide important insights as to why these groups have differences in affective regulation and impulse control. [ABSTRACT FROM AUTHOR] |
|
Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Psychology and Behavioral Sciences Collection |
