Is MAO-B activity in platelets associated with the occurrence of suicidality and behavioural personality traits in depressed patients?
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| Title: | Is MAO-B activity in platelets associated with the occurrence of suicidality and behavioural personality traits in depressed patients? |
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| Authors: | Lewitzka, U. (AUTHOR), Müller‐Oerlinghausen, B. (AUTHOR), Felber, W. (AUTHOR), Brunner, J. (AUTHOR), Hawellek, B. (AUTHOR), Rujescu, D. (AUTHOR), Ising, M. (AUTHOR), Lauterbach, E. (AUTHOR), Broocks, A. (AUTHOR), Bondy, B. (AUTHOR), Rao, M. L. (AUTHOR), Frahnert, C. (AUTHOR), Heuser, I. (AUTHOR), Hohagen, F. (AUTHOR), Maier, W. (AUTHOR), Bronisch, T. (AUTHOR) |
| Source: | Acta Psychiatrica Scandinavica. Jan2008, Vol. 117 Issue 1, p41-49. 9p. 4 Charts. |
| Subjects: | Blood platelets, Mental depression, Personality, Affective disorders, Patients |
| Abstract: | Objective: Low platelet monoaminoxidase B (MAO-B) activity has been associated with various forms of impulsive behaviour and suicidality. The present study investigated the relationship between MAO-B activity in platelets and aspects of suicidality in depressed patients and controls. Method: In 87 patients with affective spectrum disorders (58% suffering from a major depressive episode – MDE) the potential association between platelet MAO-B activity and suicidality was examined. Fifty-nine of the patients had committed suicide attempt recently (SA –‘suicide attempters’), 28 patients were acutely depressed without having shown suicidal thoughts or suicidal behaviour in the past (NA –‘non-suicide attempters’). Results: The SA and NA were comparable as to their diagnoses and general demographic and psychopathological parameters. MAO-B activity did not differ between SA and NA. No systematic correlations existed between MAO-B activity and any dimensions of suicidal behaviour or psychopathology. As a single finding only a weak positive association of higher MAO-B activity in SA with a fatal intention of the SA was observed. Conclusion: Our findings do not support a consistent association of platelet MAO-B activity and suicidal behaviour in general, but specific facts of suicidality might be associated. [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | Objective: Low platelet monoaminoxidase B (MAO-B) activity has been associated with various forms of impulsive behaviour and suicidality. The present study investigated the relationship between MAO-B activity in platelets and aspects of suicidality in depressed patients and controls. Method: In 87 patients with affective spectrum disorders (58% suffering from a major depressive episode – MDE) the potential association between platelet MAO-B activity and suicidality was examined. Fifty-nine of the patients had committed suicide attempt recently (SA –‘suicide attempters’), 28 patients were acutely depressed without having shown suicidal thoughts or suicidal behaviour in the past (NA –‘non-suicide attempters’). Results: The SA and NA were comparable as to their diagnoses and general demographic and psychopathological parameters. MAO-B activity did not differ between SA and NA. No systematic correlations existed between MAO-B activity and any dimensions of suicidal behaviour or psychopathology. As a single finding only a weak positive association of higher MAO-B activity in SA with a fatal intention of the SA was observed. Conclusion: Our findings do not support a consistent association of platelet MAO-B activity and suicidal behaviour in general, but specific facts of suicidality might be associated. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 0001690X |
| DOI: | 10.1111/j.1600-0447.2007.01121.x |
