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Is MAO-B activity in platelets associated with the occurrence of suicidality and behavioural personality traits in depressed patients?

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Title: Is MAO-B activity in platelets associated with the occurrence of suicidality and behavioural personality traits in depressed patients?
Authors: Lewitzka, U. (AUTHOR), Müller‐Oerlinghausen, B. (AUTHOR), Felber, W. (AUTHOR), Brunner, J. (AUTHOR), Hawellek, B. (AUTHOR), Rujescu, D. (AUTHOR), Ising, M. (AUTHOR), Lauterbach, E. (AUTHOR), Broocks, A. (AUTHOR), Bondy, B. (AUTHOR), Rao, M. L. (AUTHOR), Frahnert, C. (AUTHOR), Heuser, I. (AUTHOR), Hohagen, F. (AUTHOR), Maier, W. (AUTHOR), Bronisch, T. (AUTHOR)
Source: Acta Psychiatrica Scandinavica. Jan2008, Vol. 117 Issue 1, p41-49. 9p. 4 Charts.
Subjects: Blood platelets, Mental depression, Personality, Affective disorders, Patients
Abstract: Objective: Low platelet monoaminoxidase B (MAO-B) activity has been associated with various forms of impulsive behaviour and suicidality. The present study investigated the relationship between MAO-B activity in platelets and aspects of suicidality in depressed patients and controls. Method: In 87 patients with affective spectrum disorders (58% suffering from a major depressive episode – MDE) the potential association between platelet MAO-B activity and suicidality was examined. Fifty-nine of the patients had committed suicide attempt recently (SA –‘suicide attempters’), 28 patients were acutely depressed without having shown suicidal thoughts or suicidal behaviour in the past (NA –‘non-suicide attempters’). Results: The SA and NA were comparable as to their diagnoses and general demographic and psychopathological parameters. MAO-B activity did not differ between SA and NA. No systematic correlations existed between MAO-B activity and any dimensions of suicidal behaviour or psychopathology. As a single finding only a weak positive association of higher MAO-B activity in SA with a fatal intention of the SA was observed. Conclusion: Our findings do not support a consistent association of platelet MAO-B activity and suicidal behaviour in general, but specific facts of suicidality might be associated. [ABSTRACT FROM AUTHOR]
Copyright of Acta Psychiatrica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Is MAO-B activity in platelets associated with the occurrence of suicidality and behavioural personality traits in depressed patients?
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  Data: <searchLink fieldCode="AR" term="%22Lewitzka%2C+U%2E%22">Lewitzka, U.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Müller‐Oerlinghausen%2C+B%2E%22">Müller‐Oerlinghausen, B.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Felber%2C+W%2E%22">Felber, W.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Brunner%2C+J%2E%22">Brunner, J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hawellek%2C+B%2E%22">Hawellek, B.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rujescu%2C+D%2E%22">Rujescu, D.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ising%2C+M%2E%22">Ising, M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lauterbach%2C+E%2E%22">Lauterbach, E.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Broocks%2C+A%2E%22">Broocks, A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bondy%2C+B%2E%22">Bondy, B.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rao%2C+M%2E+L%2E%22">Rao, M. L.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Frahnert%2C+C%2E%22">Frahnert, C.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Heuser%2C+I%2E%22">Heuser, I.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hohagen%2C+F%2E%22">Hohagen, F.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Maier%2C+W%2E%22">Maier, W.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bronisch%2C+T%2E%22">Bronisch, T.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Acta+Psychiatrica+Scandinavica%22">Acta Psychiatrica Scandinavica</searchLink>. Jan2008, Vol. 117 Issue 1, p41-49. 9p. 4 Charts.
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  Data: <searchLink fieldCode="DE" term="%22Blood+platelets%22">Blood platelets</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Personality%22">Personality</searchLink><br /><searchLink fieldCode="DE" term="%22Affective+disorders%22">Affective disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Patients%22">Patients</searchLink>
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  Data: Objective: Low platelet monoaminoxidase B (MAO-B) activity has been associated with various forms of impulsive behaviour and suicidality. The present study investigated the relationship between MAO-B activity in platelets and aspects of suicidality in depressed patients and controls. Method: In 87 patients with affective spectrum disorders (58% suffering from a major depressive episode – MDE) the potential association between platelet MAO-B activity and suicidality was examined. Fifty-nine of the patients had committed suicide attempt recently (SA –‘suicide attempters’), 28 patients were acutely depressed without having shown suicidal thoughts or suicidal behaviour in the past (NA –‘non-suicide attempters’). Results: The SA and NA were comparable as to their diagnoses and general demographic and psychopathological parameters. MAO-B activity did not differ between SA and NA. No systematic correlations existed between MAO-B activity and any dimensions of suicidal behaviour or psychopathology. As a single finding only a weak positive association of higher MAO-B activity in SA with a fatal intention of the SA was observed. Conclusion: Our findings do not support a consistent association of platelet MAO-B activity and suicidal behaviour in general, but specific facts of suicidality might be associated. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Acta Psychiatrica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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