Indinavir concentrations and St John's wort.
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| Title: | Indinavir concentrations and St John's wort. |
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| Authors: | Piscitelli, Stephen C., Burstein, Aaron H., Chaitt, Doreen, Alfaro, Raul M., Falloon, Judith |
| Source: | Lancet. 2/12/2000, Vol. 355 Issue 9203, p547. 2p. 1 Graph. |
| Subjects: | Hypericum perforatum, Hypericum, HIV, National Institute of Allergy & Infectious Diseases (U.S.), Testing, Therapeutics |
| Geographic Terms: | United Kingdom |
| Abstract: | St John's wort reduced the area under the curve of the HIV-1 protease inhibitor indinavir by a mean of 57% (SD 19) and decreased the extrapolated 8-h indinavir trough by 81% (16) in healthy volunteers. A reduction in indinavir exposure of this magnitude could lead to the development of drug resistance and treatment failure. [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | St John's wort reduced the area under the curve of the HIV-1 protease inhibitor indinavir by a mean of 57% (SD 19) and decreased the extrapolated 8-h indinavir trough by 81% (16) in healthy volunteers. A reduction in indinavir exposure of this magnitude could lead to the development of drug resistance and treatment failure. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 01406736 |
| DOI: | 10.1016/S0140-6736(99)05712-8 |
