Analysis of the alpha-synuclein G209A mutation in familial Parkinson's disease.
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| Title: | Analysis of the alpha-synuclein G209A mutation in familial Parkinson's disease. |
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| Authors: | Zareparsi, Sepideh, Kay, Jeffrey, Camicioli, Richard, Kramer, Patricia, Nutt, John, Bird, Thomas, Litt, Michael, Payami, Haydeh, Zareparsi, S (AUTHOR), Kaye, J (AUTHOR), Camicioli, R (AUTHOR), Kramer, P (AUTHOR), Nutt, J (AUTHOR), Bird, T (AUTHOR), Litt, M (AUTHOR), Payami, H (AUTHOR), Kay, J (AUTHOR) |
| Source: | Lancet. 1/3/1998, Vol. 351 Issue 9095, p37-38. 2p. |
| Subjects: | Parkinson's disease & genetics, Brain diseases, Genetics, Age factors in disease, Comparative studies, Genealogy, Genetic techniques, Research methodology, Medical cooperation, Genetic mutation, Nerve tissue proteins, Parkinson's disease, Research, Evaluation research |
| Abstract: | Presents research which sought to test whether a mutation in the alpha-synuclein gene on chromosome 4q21-23 is responsible for Parkinson's disease (PD) in white PD families of northern European origin. Previous research; None of subjects having mutation at G209A position; Linkage analysis; No positive evidence for linkage in most families; Alpha-synuclein not responsible for PD in these families. |
| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | Presents research which sought to test whether a mutation in the alpha-synuclein gene on chromosome 4q21-23 is responsible for Parkinson's disease (PD) in white PD families of northern European origin. Previous research; None of subjects having mutation at G209A position; Linkage analysis; No positive evidence for linkage in most families; Alpha-synuclein not responsible for PD in these families. |
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| ISSN: | 01406736 |
| DOI: | 10.1016/S0140-6736(05)78089-2 |
