View in EDS

Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial.

Saved in:
Bibliographic Details
Title: Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial.
Authors: Beaulieu, Andre, Rubbert-Roth, Andrea, Ramos-Remus, Cesar, Rovensky, Josef, Alecock, Emma, Woodworth, Thasia, Alten, Rieke, Smolen, Josef S.
Source: Lancet. 3/22/2008, Vol. 371 Issue 9617, p987-997. 11p.
Subjects: Rheumatoid arthritis, Autoimmune diseases, Arthritis patients, Drug efficacy, Interleukin-6, Interleukins, Patients
Abstract: The article focuses on research on rheumatoid arthritis which was done in an effort to assess the therapeutic effects of blocking interleukin 6 with the inhibition of the interleukin 6 receptor with tocilizumab in patients with rheumatoid arthritis. Researchers used a double blind, randomised, placebo controlled study which looked at 623 arthritis patients. They found that patients receiving tocilizumab had improvement in swollen and tender joints. They concluded that tocilizumab could be an effective therapeutic approach in patients with moderate to severe arthritis.
Database: Psychology and Behavioral Sciences Collection
FullText Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 31413232
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Beaulieu%2C+Andre%22">Beaulieu, Andre</searchLink><br /><searchLink fieldCode="AR" term="%22Rubbert-Roth%2C+Andrea%22">Rubbert-Roth, Andrea</searchLink><br /><searchLink fieldCode="AR" term="%22Ramos-Remus%2C+Cesar%22">Ramos-Remus, Cesar</searchLink><br /><searchLink fieldCode="AR" term="%22Rovensky%2C+Josef%22">Rovensky, Josef</searchLink><br /><searchLink fieldCode="AR" term="%22Alecock%2C+Emma%22">Alecock, Emma</searchLink><br /><searchLink fieldCode="AR" term="%22Woodworth%2C+Thasia%22">Woodworth, Thasia</searchLink><br /><searchLink fieldCode="AR" term="%22Alten%2C+Rieke%22">Alten, Rieke</searchLink><br /><searchLink fieldCode="AR" term="%22Smolen%2C+Josef+S%2E%22">Smolen, Josef S.</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Lancet%22">Lancet</searchLink>. 3/22/2008, Vol. 371 Issue 9617, p987-997. 11p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Rheumatoid+arthritis%22">Rheumatoid arthritis</searchLink><br /><searchLink fieldCode="DE" term="%22Autoimmune+diseases%22">Autoimmune diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Arthritis+patients%22">Arthritis patients</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+efficacy%22">Drug efficacy</searchLink><br /><searchLink fieldCode="DE" term="%22Interleukin-6%22">Interleukin-6</searchLink><br /><searchLink fieldCode="DE" term="%22Interleukins%22">Interleukins</searchLink><br /><searchLink fieldCode="DE" term="%22Patients%22">Patients</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The article focuses on research on rheumatoid arthritis which was done in an effort to assess the therapeutic effects of blocking interleukin 6 with the inhibition of the interleukin 6 receptor with tocilizumab in patients with rheumatoid arthritis. Researchers used a double blind, randomised, placebo controlled study which looked at 623 arthritis patients. They found that patients receiving tocilizumab had improvement in swollen and tender joints. They concluded that tocilizumab could be an effective therapeutic approach in patients with moderate to severe arthritis.
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=31413232
RecordInfo BibRecord:
  BibEntity:
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 11
        StartPage: 987
    Subjects:
      – SubjectFull: Rheumatoid arthritis
        Type: general
      – SubjectFull: Autoimmune diseases
        Type: general
      – SubjectFull: Arthritis patients
        Type: general
      – SubjectFull: Drug efficacy
        Type: general
      – SubjectFull: Interleukin-6
        Type: general
      – SubjectFull: Interleukins
        Type: general
      – SubjectFull: Patients
        Type: general
    Titles:
      – TitleFull: Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Beaulieu, Andre
      – PersonEntity:
          Name:
            NameFull: Rubbert-Roth, Andrea
      – PersonEntity:
          Name:
            NameFull: Ramos-Remus, Cesar
      – PersonEntity:
          Name:
            NameFull: Rovensky, Josef
      – PersonEntity:
          Name:
            NameFull: Alecock, Emma
      – PersonEntity:
          Name:
            NameFull: Woodworth, Thasia
      – PersonEntity:
          Name:
            NameFull: Alten, Rieke
      – PersonEntity:
          Name:
            NameFull: Smolen, Josef S.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 22
              M: 03
              Text: 3/22/2008
              Type: published
              Y: 2008
          Identifiers:
            – Type: issn-print
              Value: 01406736
          Numbering:
            – Type: volume
              Value: 371
            – Type: issue
              Value: 9617
          Titles:
            – TitleFull: Lancet
              Type: main
ResultId 1