Multiple alpha-synuclein gene polymorphisms are associated with Parkinson’s disease in a Norwegian population.

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Title:	Multiple alpha-synuclein gene polymorphisms are associated with Parkinson’s disease in a Norwegian population.
Authors:	Myhre, R., Toft, M., Kachergus, J., Hulihan, M. M., Aasly, J. O., Klungland, H., Farrer, M. J.
Source:	Acta Neurologica Scandinavica. Nov2008, Vol. 118 Issue 5, p320-327. 8p. 1 Color Photograph, 2 Diagrams, 2 Charts.
Subjects:	Parkinson's disease, Genetic polymorphisms, Promoters (Genetics), Genomes, Gene expression
Abstract:	Objectives – Previous studies have found associations between Parkinson’s disease (PD) and polymorphisms located within both the alpha-synuclein gene ( SNCA) promoter and other gene regions. Our aim was to study SNCA gene markers in a closely matched Norwegian PD population to examine the genetic relationship between different polymorphisms associated with the disease. Methods – We genotyped seven single nucleotide polymorphisms (SNPs) located in the SNCA promoter and two SNPs in the 3′ gene region and seven microsatellite markers located across the gene in a closely matched series of 236 PD patients and 236 controls. Linkage disequilibrium (LD) structure was examined, and association of single markers and gene haplotypes analyzed. Results – Several markers located across the SNCA gene were associated with PD, including marker alleles associated with disease in previous studies (Rep1 263-bp allele, rs356165 and rs356219). Conclusion – LD between associated marker alleles located across the SNCA gene suggests that a single genetic effect might explain the previous reported association in the promoter and 3′ regions. [ABSTRACT FROM AUTHOR]
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Database:	Psychology and Behavioral Sciences Collection

Description
Abstract:	Objectives – Previous studies have found associations between Parkinson’s disease (PD) and polymorphisms located within both the alpha-synuclein gene ( SNCA) promoter and other gene regions. Our aim was to study SNCA gene markers in a closely matched Norwegian PD population to examine the genetic relationship between different polymorphisms associated with the disease. Methods – We genotyped seven single nucleotide polymorphisms (SNPs) located in the SNCA promoter and two SNPs in the 3′ gene region and seven microsatellite markers located across the gene in a closely matched series of 236 PD patients and 236 controls. Linkage disequilibrium (LD) structure was examined, and association of single markers and gene haplotypes analyzed. Results – Several markers located across the SNCA gene were associated with PD, including marker alleles associated with disease in previous studies (Rep1 263-bp allele, rs356165 and rs356219). Conclusion – LD between associated marker alleles located across the SNCA gene suggests that a single genetic effect might explain the previous reported association in the promoter and 3′ regions. [ABSTRACT FROM AUTHOR]
ISSN:	00016314
DOI:	10.1111/j.1600-0404.2008.01019.x