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Multiple alpha-synuclein gene polymorphisms are associated with Parkinson’s disease in a Norwegian population.

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Title: Multiple alpha-synuclein gene polymorphisms are associated with Parkinson’s disease in a Norwegian population.
Authors: Myhre, R., Toft, M., Kachergus, J., Hulihan, M. M., Aasly, J. O., Klungland, H., Farrer, M. J.
Source: Acta Neurologica Scandinavica. Nov2008, Vol. 118 Issue 5, p320-327. 8p. 1 Color Photograph, 2 Diagrams, 2 Charts.
Subjects: Parkinson's disease, Genetic polymorphisms, Promoters (Genetics), Genomes, Gene expression
Abstract: Objectives – Previous studies have found associations between Parkinson’s disease (PD) and polymorphisms located within both the alpha-synuclein gene ( SNCA) promoter and other gene regions. Our aim was to study SNCA gene markers in a closely matched Norwegian PD population to examine the genetic relationship between different polymorphisms associated with the disease. Methods – We genotyped seven single nucleotide polymorphisms (SNPs) located in the SNCA promoter and two SNPs in the 3′ gene region and seven microsatellite markers located across the gene in a closely matched series of 236 PD patients and 236 controls. Linkage disequilibrium (LD) structure was examined, and association of single markers and gene haplotypes analyzed. Results – Several markers located across the SNCA gene were associated with PD, including marker alleles associated with disease in previous studies (Rep1 263-bp allele, rs356165 and rs356219). Conclusion – LD between associated marker alleles located across the SNCA gene suggests that a single genetic effect might explain the previous reported association in the promoter and 3′ regions. [ABSTRACT FROM AUTHOR]
Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Multiple alpha-synuclein gene polymorphisms are associated with Parkinson’s disease in a Norwegian population.
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  Data: <searchLink fieldCode="AR" term="%22Myhre%2C+R%2E%22">Myhre, R.</searchLink><br /><searchLink fieldCode="AR" term="%22Toft%2C+M%2E%22">Toft, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Kachergus%2C+J%2E%22">Kachergus, J.</searchLink><br /><searchLink fieldCode="AR" term="%22Hulihan%2C+M%2E+M%2E%22">Hulihan, M. M.</searchLink><br /><searchLink fieldCode="AR" term="%22Aasly%2C+J%2E+O%2E%22">Aasly, J. O.</searchLink><br /><searchLink fieldCode="AR" term="%22Klungland%2C+H%2E%22">Klungland, H.</searchLink><br /><searchLink fieldCode="AR" term="%22Farrer%2C+M%2E+J%2E%22">Farrer, M. J.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Acta+Neurologica+Scandinavica%22">Acta Neurologica Scandinavica</searchLink>. Nov2008, Vol. 118 Issue 5, p320-327. 8p. 1 Color Photograph, 2 Diagrams, 2 Charts.
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  Data: <searchLink fieldCode="DE" term="%22Parkinson's+disease%22">Parkinson's disease</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+polymorphisms%22">Genetic polymorphisms</searchLink><br /><searchLink fieldCode="DE" term="%22Promoters+%28Genetics%29%22">Promoters (Genetics)</searchLink><br /><searchLink fieldCode="DE" term="%22Genomes%22">Genomes</searchLink><br /><searchLink fieldCode="DE" term="%22Gene+expression%22">Gene expression</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Objectives – Previous studies have found associations between Parkinson’s disease (PD) and polymorphisms located within both the alpha-synuclein gene ( SNCA) promoter and other gene regions. Our aim was to study SNCA gene markers in a closely matched Norwegian PD population to examine the genetic relationship between different polymorphisms associated with the disease. Methods – We genotyped seven single nucleotide polymorphisms (SNPs) located in the SNCA promoter and two SNPs in the 3′ gene region and seven microsatellite markers located across the gene in a closely matched series of 236 PD patients and 236 controls. Linkage disequilibrium (LD) structure was examined, and association of single markers and gene haplotypes analyzed. Results – Several markers located across the SNCA gene were associated with PD, including marker alleles associated with disease in previous studies (Rep1 263-bp allele, rs356165 and rs356219). Conclusion – LD between associated marker alleles located across the SNCA gene suggests that a single genetic effect might explain the previous reported association in the promoter and 3′ regions. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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              Text: Nov2008
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