Intracellular action of the cytokine MIF to modulate MP-1 activity and the cell cycle through Jab1.

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Bibliographic Details
Title:	Intracellular action of the cytokine MIF to modulate MP-1 activity and the cell cycle through Jab1.
Authors:	Kleeman, Robert, Hausser, Angelika, Gelger, Georg, Mischke, Ralf, Burger-Kentischer, Anke, Flieger, Oliver, Johannes, Franz-Josef, Roger, Thierry, Calandra, Thierry, Kapurniotu, Aphrodite, Grell, Matthias, Finkelmeier, Doris, Brunner, Herwig, Bernhagen, Jurgen
Source:	Nature. 11/9/2000, Vol. 408 Issue 6809, p211. 6p. 6 Color Photographs, 5 Diagrams, 5 Graphs.
Subjects:	Macrophage activation, Cell migration, Protein conformation, Binding sites, Cytokines
Abstract:	Presents a report on the molecular targets of macrophage migration inhibitory factor (MIF) and its interaction with an intercellular protein, Jab 1. Background on cytokines, multifunctional mediators that modulate immune activity by receptor-mediated pathways; Details on how MIF binds Jab 1 and inhibits effects activated by the protein; Conclusion that MIF acts broadly to negatively regulate Jab1-controlled pathways, and that this interaction may provide a molecular basis for MIF activities.
Database:	Psychology and Behavioral Sciences Collection

Description
Abstract:	Presents a report on the molecular targets of macrophage migration inhibitory factor (MIF) and its interaction with an intercellular protein, Jab 1. Background on cytokines, multifunctional mediators that modulate immune activity by receptor-mediated pathways; Details on how MIF binds Jab 1 and inhibits effects activated by the protein; Conclusion that MIF acts broadly to negatively regulate Jab1-controlled pathways, and that this interaction may provide a molecular basis for MIF activities.
ISSN:	00280836
DOI:	10.1038/35041591