Intracellular action of the cytokine MIF to modulate MP-1 activity and the cell cycle through Jab1.
Saved in:
| Title: | Intracellular action of the cytokine MIF to modulate MP-1 activity and the cell cycle through Jab1. |
|---|---|
| Authors: | Kleeman, Robert, Hausser, Angelika, Gelger, Georg, Mischke, Ralf, Burger-Kentischer, Anke, Flieger, Oliver, Johannes, Franz-Josef, Roger, Thierry, Calandra, Thierry, Kapurniotu, Aphrodite, Grell, Matthias, Finkelmeier, Doris, Brunner, Herwig, Bernhagen, Jurgen |
| Source: | Nature. 11/9/2000, Vol. 408 Issue 6809, p211. 6p. 6 Color Photographs, 5 Diagrams, 5 Graphs. |
| Subjects: | Macrophage activation, Cell migration, Protein conformation, Binding sites, Cytokines |
| Abstract: | Presents a report on the molecular targets of macrophage migration inhibitory factor (MIF) and its interaction with an intercellular protein, Jab 1. Background on cytokines, multifunctional mediators that modulate immune activity by receptor-mediated pathways; Details on how MIF binds Jab 1 and inhibits effects activated by the protein; Conclusion that MIF acts broadly to negatively regulate Jab1-controlled pathways, and that this interaction may provide a molecular basis for MIF activities. |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
|---|---|
| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 3773425 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Intracellular action of the cytokine MIF to modulate MP-1 activity and the cell cycle through Jab1. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Kleeman%2C+Robert%22">Kleeman, Robert</searchLink><br /><searchLink fieldCode="AR" term="%22Hausser%2C+Angelika%22">Hausser, Angelika</searchLink><br /><searchLink fieldCode="AR" term="%22Gelger%2C+Georg%22">Gelger, Georg</searchLink><br /><searchLink fieldCode="AR" term="%22Mischke%2C+Ralf%22">Mischke, Ralf</searchLink><br /><searchLink fieldCode="AR" term="%22Burger-Kentischer%2C+Anke%22">Burger-Kentischer, Anke</searchLink><br /><searchLink fieldCode="AR" term="%22Flieger%2C+Oliver%22">Flieger, Oliver</searchLink><br /><searchLink fieldCode="AR" term="%22Johannes%2C+Franz-Josef%22">Johannes, Franz-Josef</searchLink><br /><searchLink fieldCode="AR" term="%22Roger%2C+Thierry%22">Roger, Thierry</searchLink><br /><searchLink fieldCode="AR" term="%22Calandra%2C+Thierry%22">Calandra, Thierry</searchLink><br /><searchLink fieldCode="AR" term="%22Kapurniotu%2C+Aphrodite%22">Kapurniotu, Aphrodite</searchLink><br /><searchLink fieldCode="AR" term="%22Grell%2C+Matthias%22">Grell, Matthias</searchLink><br /><searchLink fieldCode="AR" term="%22Finkelmeier%2C+Doris%22">Finkelmeier, Doris</searchLink><br /><searchLink fieldCode="AR" term="%22Brunner%2C+Herwig%22">Brunner, Herwig</searchLink><br /><searchLink fieldCode="AR" term="%22Bernhagen%2C+Jurgen%22">Bernhagen, Jurgen</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Nature%22">Nature</searchLink>. 11/9/2000, Vol. 408 Issue 6809, p211. 6p. 6 Color Photographs, 5 Diagrams, 5 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Macrophage+activation%22">Macrophage activation</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+migration%22">Cell migration</searchLink><br /><searchLink fieldCode="DE" term="%22Protein+conformation%22">Protein conformation</searchLink><br /><searchLink fieldCode="DE" term="%22Binding+sites%22">Binding sites</searchLink><br /><searchLink fieldCode="DE" term="%22Cytokines%22">Cytokines</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Presents a report on the molecular targets of macrophage migration inhibitory factor (MIF) and its interaction with an intercellular protein, Jab 1. Background on cytokines, multifunctional mediators that modulate immune activity by receptor-mediated pathways; Details on how MIF binds Jab 1 and inhibits effects activated by the protein; Conclusion that MIF acts broadly to negatively regulate Jab1-controlled pathways, and that this interaction may provide a molecular basis for MIF activities. |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=3773425 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/35041591 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 6 StartPage: 211 Subjects: – SubjectFull: Macrophage activation Type: general – SubjectFull: Cell migration Type: general – SubjectFull: Protein conformation Type: general – SubjectFull: Binding sites Type: general – SubjectFull: Cytokines Type: general Titles: – TitleFull: Intracellular action of the cytokine MIF to modulate MP-1 activity and the cell cycle through Jab1. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Kleeman, Robert – PersonEntity: Name: NameFull: Hausser, Angelika – PersonEntity: Name: NameFull: Gelger, Georg – PersonEntity: Name: NameFull: Mischke, Ralf – PersonEntity: Name: NameFull: Burger-Kentischer, Anke – PersonEntity: Name: NameFull: Flieger, Oliver – PersonEntity: Name: NameFull: Johannes, Franz-Josef – PersonEntity: Name: NameFull: Roger, Thierry – PersonEntity: Name: NameFull: Calandra, Thierry – PersonEntity: Name: NameFull: Kapurniotu, Aphrodite – PersonEntity: Name: NameFull: Grell, Matthias – PersonEntity: Name: NameFull: Finkelmeier, Doris – PersonEntity: Name: NameFull: Brunner, Herwig – PersonEntity: Name: NameFull: Bernhagen, Jurgen IsPartOfRelationships: – BibEntity: Dates: – D: 09 M: 11 Text: 11/9/2000 Type: published Y: 2000 Identifiers: – Type: issn-print Value: 00280836 Numbering: – Type: volume Value: 408 – Type: issue Value: 6809 Titles: – TitleFull: Nature Type: main |
| ResultId | 1 |
