Serum creatinine is an inadequate screening test for renal failure in ischemic stroke patients.

Saved in:

Bibliographic Details
Title:	Serum creatinine is an inadequate screening test for renal failure in ischemic stroke patients.
Authors:	Piñol-Ripoll, G., de la Puerta, I., Purroy, F.
Source:	Acta Neurologica Scandinavica. Jul2009, Vol. 120 Issue 1, p47-52. 6p. 6 Charts.
Subjects:	Qualitative research, Creatinine, Ischemia, Glomerular filtration rate, Acute kidney failure, Cerebrovascular disease patients, Kidney function tests
Abstract:	Objective – Serum creatinine (SCr) level is the most commonly used screening test for renal function, but its concentration is affected by factors other than glomerular filtration rate (GFR). We hypothesized that SCr would underestimate the degree of renal failure in ischemic stroke patients. Material and methods – We conducted a prospective study of 273 patients admitted to our institution for ischemic stroke within a year. GFR was calculated using the Cockcroft–Gault formula (CG). Patients were grouped according to the SCr with stages of renal failure according to CG values. Results – Of the 273 patients studied, 231 had normal SCr. Of this group 46.8% (108), 24.7% (57) and 4 (1.7%) had mild, moderate and severe renal failure according to GFR estimation. Among patients with normal SCr, abnormal CG values were identified in 86.2% (150) ≥ 65 years old, 33.3% (19) <65 years old, 69% (89) in men and 78.4% (80) in women. An SCr greater than 1.7 mg/dl had only a sensitivity of 14.7%. Conclusions – This study documents the substantial prevalence of significantly abnormal renal function among patients with normal-range SCr. Routine estimation of GFR be preferred to SCr as a screening method for the early detection of renal impairment in stroke patients. [ABSTRACT FROM AUTHOR]
	Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database:	Psychology and Behavioral Sciences Collection

Description
Abstract:	Objective – Serum creatinine (SCr) level is the most commonly used screening test for renal function, but its concentration is affected by factors other than glomerular filtration rate (GFR). We hypothesized that SCr would underestimate the degree of renal failure in ischemic stroke patients. Material and methods – We conducted a prospective study of 273 patients admitted to our institution for ischemic stroke within a year. GFR was calculated using the Cockcroft–Gault formula (CG). Patients were grouped according to the SCr with stages of renal failure according to CG values. Results – Of the 273 patients studied, 231 had normal SCr. Of this group 46.8% (108), 24.7% (57) and 4 (1.7%) had mild, moderate and severe renal failure according to GFR estimation. Among patients with normal SCr, abnormal CG values were identified in 86.2% (150) ≥ 65 years old, 33.3% (19) <65 years old, 69% (89) in men and 78.4% (80) in women. An SCr greater than 1.7 mg/dl had only a sensitivity of 14.7%. Conclusions – This study documents the substantial prevalence of significantly abnormal renal function among patients with normal-range SCr. Routine estimation of GFR be preferred to SCr as a screening method for the early detection of renal impairment in stroke patients. [ABSTRACT FROM AUTHOR]
ISSN:	00016314
DOI:	10.1111/j.1600-0404.2008.01120.x