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Cancer biology: Cancer's metabolic roots.

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Title: Cancer biology: Cancer's metabolic roots.
Source: Nature. 7/30/2009, Vol. 460 Issue 7255, p554-554. 1p.
Subjects: Tumor genetics, Genetic mutation, Rutter, Jared, Succinate dehydrogenase, Carcinogenesis, Neuroendocrine tumors
Abstract: The article cites a study which found a link between a mutation in a protein and a development of a type of tumour. A team led by Jared Rutter determined the function of SDH5, a structural protein of the enzyme succinate dehydrogenase (SDH). It is noted that the neuroendocrine tumour called paraganglioma is attributed to human mutations that inhibit SDH activity, thus signifying a metabolic cause of the tumour.
Database: Psychology and Behavioral Sciences Collection
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DbLabel: Psychology and Behavioral Sciences Collection
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PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Cancer biology: Cancer's metabolic roots.
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  Data: <searchLink fieldCode="JN" term="%22Nature%22">Nature</searchLink>. 7/30/2009, Vol. 460 Issue 7255, p554-554. 1p.
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  Data: <searchLink fieldCode="DE" term="%22Tumor+genetics%22">Tumor genetics</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+mutation%22">Genetic mutation</searchLink><br /><searchLink fieldCode="DE" term="%22Rutter%2C+Jared%22">Rutter, Jared</searchLink><br /><searchLink fieldCode="DE" term="%22Succinate+dehydrogenase%22">Succinate dehydrogenase</searchLink><br /><searchLink fieldCode="DE" term="%22Carcinogenesis%22">Carcinogenesis</searchLink><br /><searchLink fieldCode="DE" term="%22Neuroendocrine+tumors%22">Neuroendocrine tumors</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: The article cites a study which found a link between a mutation in a protein and a development of a type of tumour. A team led by Jared Rutter determined the function of SDH5, a structural protein of the enzyme succinate dehydrogenase (SDH). It is noted that the neuroendocrine tumour called paraganglioma is attributed to human mutations that inhibit SDH activity, thus signifying a metabolic cause of the tumour.
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=43455947
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    Identifiers:
      – Type: doi
        Value: 10.1038/460554d
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      – Code: eng
        Text: English
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        PageCount: 1
        StartPage: 554
    Subjects:
      – SubjectFull: Tumor genetics
        Type: general
      – SubjectFull: Genetic mutation
        Type: general
      – SubjectFull: Rutter, Jared
        Type: general
      – SubjectFull: Succinate dehydrogenase
        Type: general
      – SubjectFull: Carcinogenesis
        Type: general
      – SubjectFull: Neuroendocrine tumors
        Type: general
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      – TitleFull: Cancer biology: Cancer's metabolic roots.
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              Text: 7/30/2009
              Type: published
              Y: 2009
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              Value: 460
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