The heritability of P300 amplitude in 18-year-olds is robust to adolescent alcohol use.
Saved in:
| Title: | The heritability of P300 amplitude in 18-year-olds is robust to adolescent alcohol use. |
|---|---|
| Authors: | Perlman, Greg (AUTHOR), Johnson, Wendy (AUTHOR), Iacono, William G. (AUTHOR) |
| Source: | Psychophysiology. Sep2009, Vol. 46 Issue 5, p962-969. 8p. 1 Diagram, 2 Charts, 3 Graphs. |
| Subjects: | Therapeutic use of alcohol, Genotype-environment interaction, Ecological genetics, Phenotypic plasticity, Controlled drinking |
| Abstract: | P3 amplitude reduction (P3AR) is associated with adolescent alcohol use (AAU) and highly heritable, suggesting that P3AR may index a genetic predisposition (e.g., an endophenotype) for AAU. However, because P3AR and AAU covary naturally in the population, these observations are also consistent with P3AR reflecting neurotoxic effects of AAU on the developing adolescent brain. In this report, we describe the use of recent advancements in biometric modeling to examine changes in the genetic and environmental contributions to variability in P3 amplitude related to cumulative AAU by late adolescence in a large community-based twin sample. We found that the genetic and environmental contributions to variability in P3 amplitude were unaffected by AAU. This suggests that P3AR indexes risk for alcoholism independent of any deleterious effect of AAU on adolescent brain development. [ABSTRACT FROM AUTHOR] |
| Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
|
Full text is not displayed to guests.
Login for full access.
|
|
| Abstract: | P3 amplitude reduction (P3AR) is associated with adolescent alcohol use (AAU) and highly heritable, suggesting that P3AR may index a genetic predisposition (e.g., an endophenotype) for AAU. However, because P3AR and AAU covary naturally in the population, these observations are also consistent with P3AR reflecting neurotoxic effects of AAU on the developing adolescent brain. In this report, we describe the use of recent advancements in biometric modeling to examine changes in the genetic and environmental contributions to variability in P3 amplitude related to cumulative AAU by late adolescence in a large community-based twin sample. We found that the genetic and environmental contributions to variability in P3 amplitude were unaffected by AAU. This suggests that P3AR indexes risk for alcoholism independent of any deleterious effect of AAU on adolescent brain development. [ABSTRACT FROM AUTHOR] |
|---|---|
| ISSN: | 00485772 |
| DOI: | 10.1111/j.1469-8986.2009.00850.x |
