Bibliographic Details
| Title: |
Clomipramine enhances the cortisol response to 5-HTP: implications for the therapeutic role of 5-HT[sub 2] receptors. |
| Authors: |
Sargent, P. A., Quested, D. J., Cowen, P. J. |
| Source: |
Psychopharmacology. 1998, Vol. 140 Issue 1, p120. 3p. |
| Subjects: |
Hydroxytryptophan, Antidepressants, Serotonin uptake inhibitors, Hydrocortisone |
| Abstract: |
Abstract We measured the cortisol response to the 5-HT precursor, 5-hydroxytryptophan, (5-HTP) in seven patients with major depression before and after 8 weeks treatment with the tricyclic antidepressant, clomipramine. The cortisol response to 5-HTP was significantly increased following clomipramine treatment, suggesting that clomipramine, like selective serotonin re-uptake inhibitors (SSRIs), enhances this 5-HT[sub 2] receptor mediated response. Because other tricyclic antidepressants do not increase 5-HTP-mediated cortisol release, it seems unlikely that enhancement of 5-HT[sub 2] receptor function is a critical mechanism for antidepressant action. However, facilitation of neurotransmission at 5-HT[sub 2] receptors could account for the efficacy of clomipramine and SSRIs in the treatment of obsessive compulsive disorder and also for their liability to cause orgasmic dysfunction. [ABSTRACT FROM AUTHOR] |
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| Database: |
Psychology and Behavioral Sciences Collection |
