Clomipramine enhances the cortisol response to 5-HTP: implications for the therapeutic role of 5-HT[sub 2] receptors.
Saved in:
| Title: | Clomipramine enhances the cortisol response to 5-HTP: implications for the therapeutic role of 5-HT[sub 2] receptors. |
|---|---|
| Authors: | Sargent, P. A., Quested, D. J., Cowen, P. J. |
| Source: | Psychopharmacology. 1998, Vol. 140 Issue 1, p120. 3p. |
| Subjects: | Hydroxytryptophan, Antidepressants, Serotonin uptake inhibitors, Hydrocortisone |
| Abstract: | Abstract We measured the cortisol response to the 5-HT precursor, 5-hydroxytryptophan, (5-HTP) in seven patients with major depression before and after 8 weeks treatment with the tricyclic antidepressant, clomipramine. The cortisol response to 5-HTP was significantly increased following clomipramine treatment, suggesting that clomipramine, like selective serotonin re-uptake inhibitors (SSRIs), enhances this 5-HT[sub 2] receptor mediated response. Because other tricyclic antidepressants do not increase 5-HTP-mediated cortisol release, it seems unlikely that enhancement of 5-HT[sub 2] receptor function is a critical mechanism for antidepressant action. However, facilitation of neurotransmission at 5-HT[sub 2] receptors could account for the efficacy of clomipramine and SSRIs in the treatment of obsessive compulsive disorder and also for their liability to cause orgasmic dysfunction. [ABSTRACT FROM AUTHOR] |
| Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
|---|---|
| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 4694082 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Clomipramine enhances the cortisol response to 5-HTP: implications for the therapeutic role of 5-HT[sub 2] receptors. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Sargent%2C+P%2E+A%2E%22">Sargent, P. A.</searchLink><br /><searchLink fieldCode="AR" term="%22Quested%2C+D%2E+J%2E%22">Quested, D. J.</searchLink><br /><searchLink fieldCode="AR" term="%22Cowen%2C+P%2E+J%2E%22">Cowen, P. J.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Psychopharmacology%22">Psychopharmacology</searchLink>. 1998, Vol. 140 Issue 1, p120. 3p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Hydroxytryptophan%22">Hydroxytryptophan</searchLink><br /><searchLink fieldCode="DE" term="%22Antidepressants%22">Antidepressants</searchLink><br /><searchLink fieldCode="DE" term="%22Serotonin+uptake+inhibitors%22">Serotonin uptake inhibitors</searchLink><br /><searchLink fieldCode="DE" term="%22Hydrocortisone%22">Hydrocortisone</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Abstract We measured the cortisol response to the 5-HT precursor, 5-hydroxytryptophan, (5-HTP) in seven patients with major depression before and after 8 weeks treatment with the tricyclic antidepressant, clomipramine. The cortisol response to 5-HTP was significantly increased following clomipramine treatment, suggesting that clomipramine, like selective serotonin re-uptake inhibitors (SSRIs), enhances this 5-HT[sub 2] receptor mediated response. Because other tricyclic antidepressants do not increase 5-HTP-mediated cortisol release, it seems unlikely that enhancement of 5-HT[sub 2] receptor function is a critical mechanism for antidepressant action. However, facilitation of neurotransmission at 5-HT[sub 2] receptors could account for the efficacy of clomipramine and SSRIs in the treatment of obsessive compulsive disorder and also for their liability to cause orgasmic dysfunction. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=4694082 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s002130050747 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 3 StartPage: 120 Subjects: – SubjectFull: Hydroxytryptophan Type: general – SubjectFull: Antidepressants Type: general – SubjectFull: Serotonin uptake inhibitors Type: general – SubjectFull: Hydrocortisone Type: general Titles: – TitleFull: Clomipramine enhances the cortisol response to 5-HTP: implications for the therapeutic role of 5-HT[sub 2] receptors. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Sargent, P. A. – PersonEntity: Name: NameFull: Quested, D. J. – PersonEntity: Name: NameFull: Cowen, P. J. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 11 Text: 1998 Type: published Y: 1998 Identifiers: – Type: issn-print Value: 00333158 Numbering: – Type: volume Value: 140 – Type: issue Value: 1 Titles: – TitleFull: Psychopharmacology Type: main |
| ResultId | 1 |
