Social function in multiple X and Y chromosome disorders: XXY, XYY, XXYY, XXXY.

Saved in:

Bibliographic Details
Title:	Social function in multiple X and Y chromosome disorders: XXY, XYY, XXYY, XXXY.
Authors:	Visootsak, Jeannie, Graham, Jr., John M.
Source:	Developmental Disabilities Research Reviews. 2009, Vol. 15 Issue 4, p328-332. 5p.
Subjects:	Chromosome abnormalities, Klinefelter's syndrome, Learning disability genetics, Sex chromosomes, Chromosomes, Aneuploidy
Abstract:	Klinefelter syndrome (47,XXY) was initially described in the context of its endocrinologic and physical features; however, subsequent studies have revealed specific impairments in verbal skills and social functioning. Males with sex chromosomal aneuploidies are known to have variability in their developmental profile with the majority presenting with expressive language deficits. As a consequence of language delays, they have an increased likelihood of language-based learning disabilities and social-emotional problems that may persist through adulthood. Studies on males with 47,XXY have revealed unique behavioral and social profiles with possible vulnerability to autistic traits. The prevalence of males with more than one extra sex chromosome (e.g., 48,XXYY and 48,XXXY) and an additional Y (e.g., 47,XYY) is less common, but it is important to understand their social functioning as it provides insight into treatment implications. © 2009 Wiley-Liss, Inc. Dev Disabil Res Rev 2009;15:328–332. [ABSTRACT FROM AUTHOR]
	Copyright of Developmental Disabilities Research Reviews is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database:	Psychology and Behavioral Sciences Collection

Description
Abstract:	Klinefelter syndrome (47,XXY) was initially described in the context of its endocrinologic and physical features; however, subsequent studies have revealed specific impairments in verbal skills and social functioning. Males with sex chromosomal aneuploidies are known to have variability in their developmental profile with the majority presenting with expressive language deficits. As a consequence of language delays, they have an increased likelihood of language-based learning disabilities and social-emotional problems that may persist through adulthood. Studies on males with 47,XXY have revealed unique behavioral and social profiles with possible vulnerability to autistic traits. The prevalence of males with more than one extra sex chromosome (e.g., 48,XXYY and 48,XXXY) and an additional Y (e.g., 47,XYY) is less common, but it is important to understand their social functioning as it provides insight into treatment implications. © 2009 Wiley-Liss, Inc. Dev Disabil Res Rev 2009;15:328–332. [ABSTRACT FROM AUTHOR]
ISSN:	19405510
DOI:	10.1002/ddrr.76