Bibliographic Details
| Title: |
Abnormal neural oscillations and synchrony in schizophrenia. |
| Authors: |
Uhlhaas, Peter J., Singer, Wolf |
| Source: |
Nature Reviews Neuroscience. Feb2010, Vol. 11 Issue 2, p100-113. 14p. 1 Chart, 1 Graph. |
| Subjects: |
Diagnosis of schizophrenia, People with schizophrenia, Neural circuitry, Butyric acid, Electrophysiology, Neurosciences |
| Abstract: |
Converging evidence from electrophysiological, physiological and anatomical studies suggests that abnormalities in the synchronized oscillatory activity of neurons may have a central role in the pathophysiology of schizophrenia. Neural oscillations are a fundamental mechanism for the establishment of precise temporal relationships between neuronal responses that are in turn relevant for memory, perception and consciousness. In patients with schizophrenia, the synchronization of beta- and gamma-band activity is abnormal, suggesting a crucial role for dysfunctional oscillations in the generation of the cognitive deficits and other symptoms of the disorder. Dysfunctional oscillations may arise owing to anomalies in the brain's rhythm-generating networks of GABA (γ-aminobutyric acid) interneurons and in cortico-cortical connections. [ABSTRACT FROM AUTHOR] |
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| Database: |
Psychology and Behavioral Sciences Collection |
