Abnormal neural oscillations and synchrony in schizophrenia.
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| Title: | Abnormal neural oscillations and synchrony in schizophrenia. |
|---|---|
| Authors: | Uhlhaas, Peter J., Singer, Wolf |
| Source: | Nature Reviews Neuroscience. Feb2010, Vol. 11 Issue 2, p100-113. 14p. 1 Chart, 1 Graph. |
| Subjects: | Diagnosis of schizophrenia, People with schizophrenia, Neural circuitry, Butyric acid, Electrophysiology, Neurosciences |
| Abstract: | Converging evidence from electrophysiological, physiological and anatomical studies suggests that abnormalities in the synchronized oscillatory activity of neurons may have a central role in the pathophysiology of schizophrenia. Neural oscillations are a fundamental mechanism for the establishment of precise temporal relationships between neuronal responses that are in turn relevant for memory, perception and consciousness. In patients with schizophrenia, the synchronization of beta- and gamma-band activity is abnormal, suggesting a crucial role for dysfunctional oscillations in the generation of the cognitive deficits and other symptoms of the disorder. Dysfunctional oscillations may arise owing to anomalies in the brain's rhythm-generating networks of GABA (γ-aminobutyric acid) interneurons and in cortico-cortical connections. [ABSTRACT FROM AUTHOR] |
| Copyright of Nature Reviews Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 47602747 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Abnormal neural oscillations and synchrony in schizophrenia. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Uhlhaas%2C+Peter+J%2E%22">Uhlhaas, Peter J.</searchLink><br /><searchLink fieldCode="AR" term="%22Singer%2C+Wolf%22">Singer, Wolf</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Nature+Reviews+Neuroscience%22">Nature Reviews Neuroscience</searchLink>. Feb2010, Vol. 11 Issue 2, p100-113. 14p. 1 Chart, 1 Graph. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Diagnosis+of+schizophrenia%22">Diagnosis of schizophrenia</searchLink><br /><searchLink fieldCode="DE" term="%22People+with+schizophrenia%22">People with schizophrenia</searchLink><br /><searchLink fieldCode="DE" term="%22Neural+circuitry%22">Neural circuitry</searchLink><br /><searchLink fieldCode="DE" term="%22Butyric+acid%22">Butyric acid</searchLink><br /><searchLink fieldCode="DE" term="%22Electrophysiology%22">Electrophysiology</searchLink><br /><searchLink fieldCode="DE" term="%22Neurosciences%22">Neurosciences</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Converging evidence from electrophysiological, physiological and anatomical studies suggests that abnormalities in the synchronized oscillatory activity of neurons may have a central role in the pathophysiology of schizophrenia. Neural oscillations are a fundamental mechanism for the establishment of precise temporal relationships between neuronal responses that are in turn relevant for memory, perception and consciousness. In patients with schizophrenia, the synchronization of beta- and gamma-band activity is abnormal, suggesting a crucial role for dysfunctional oscillations in the generation of the cognitive deficits and other symptoms of the disorder. Dysfunctional oscillations may arise owing to anomalies in the brain's rhythm-generating networks of GABA (γ-aminobutyric acid) interneurons and in cortico-cortical connections. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Nature Reviews Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=47602747 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/nrn2774 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 14 StartPage: 100 Subjects: – SubjectFull: Diagnosis of schizophrenia Type: general – SubjectFull: People with schizophrenia Type: general – SubjectFull: Neural circuitry Type: general – SubjectFull: Butyric acid Type: general – SubjectFull: Electrophysiology Type: general – SubjectFull: Neurosciences Type: general Titles: – TitleFull: Abnormal neural oscillations and synchrony in schizophrenia. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Uhlhaas, Peter J. – PersonEntity: Name: NameFull: Singer, Wolf IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 02 Text: Feb2010 Type: published Y: 2010 Identifiers: – Type: issn-print Value: 1471003X Numbering: – Type: volume Value: 11 – Type: issue Value: 2 Titles: – TitleFull: Nature Reviews Neuroscience Type: main |
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