Bibliographic Details
| Title: |
Vaginal brachytherapy versus pelvic external beam radiotherapy for patients with endometrial cancer of high-intermediate risk (PORTEC-2): an open-label, non-inferiority, randomised trial. |
| Authors: |
Nout, R. A., Smit, V. T. H. B. M., Putter, H., Jürgenliemk-Schulz, I. M., Jobsen, J. J., Lutgens, L. C. H. W., van der Steen-Banasik, E. M., Mens, J. W. M., Slot, A., Stenfert Kroese, M. C., van Bunningen, B. N. F. M., Ansink, A. C., van Putten, W. U., Creutzberg, C. L. |
| Source: |
Lancet. 3/6/2010, Vol. 375 Issue 9717, p816-823. 8p. 4 Charts, 3 Graphs. |
| Subjects: |
Vaginal cancer, Cancer treatment, Radioembolization, Radiotherapy, Oncology research, Toxicity testing, Health risk assessment, Cancer relapse, Endometrial cancer, Endometrial surgery |
| Abstract: |
The article presents a study that compares the effectiveness of vaginal brachytherapy (VBT) and pelvic external beam radiotherapy (EBRT) in the prevention of vaginal recurrence after intermediate-risk endometrial carcinoma surgery. It states that the study is an open-label, non-inferiority, and randomized trial that was undertaken in 19 Dutch radiation oncology centers in which 427 patients with stage I or IIA endometrial carcinoma went through EBRT and VBT. The results showed that the rates of acute grade 1-2 gastrointestinal toxicity is lower in VBT group than the EBRT group. It concludes that VBT offers effective vaginal control with less gastrointestinal toxic effects. |
| Database: |
Psychology and Behavioral Sciences Collection |
