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Vaginal brachytherapy versus pelvic external beam radiotherapy for patients with endometrial cancer of high-intermediate risk (PORTEC-2): an open-label, non-inferiority, randomised trial.

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Title: Vaginal brachytherapy versus pelvic external beam radiotherapy for patients with endometrial cancer of high-intermediate risk (PORTEC-2): an open-label, non-inferiority, randomised trial.
Authors: Nout, R. A., Smit, V. T. H. B. M., Putter, H., Jürgenliemk-Schulz, I. M., Jobsen, J. J., Lutgens, L. C. H. W., van der Steen-Banasik, E. M., Mens, J. W. M., Slot, A., Stenfert Kroese, M. C., van Bunningen, B. N. F. M., Ansink, A. C., van Putten, W. U., Creutzberg, C. L.
Source: Lancet. 3/6/2010, Vol. 375 Issue 9717, p816-823. 8p. 4 Charts, 3 Graphs.
Subjects: Vaginal cancer, Cancer treatment, Radioembolization, Radiotherapy, Oncology research, Toxicity testing, Health risk assessment, Cancer relapse, Endometrial cancer, Endometrial surgery
Abstract: The article presents a study that compares the effectiveness of vaginal brachytherapy (VBT) and pelvic external beam radiotherapy (EBRT) in the prevention of vaginal recurrence after intermediate-risk endometrial carcinoma surgery. It states that the study is an open-label, non-inferiority, and randomized trial that was undertaken in 19 Dutch radiation oncology centers in which 427 patients with stage I or IIA endometrial carcinoma went through EBRT and VBT. The results showed that the rates of acute grade 1-2 gastrointestinal toxicity is lower in VBT group than the EBRT group. It concludes that VBT offers effective vaginal control with less gastrointestinal toxic effects.
Database: Psychology and Behavioral Sciences Collection
FullText Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 48491188
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
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  Data: Vaginal brachytherapy versus pelvic external beam radiotherapy for patients with endometrial cancer of high-intermediate risk (PORTEC-2): an open-label, non-inferiority, randomised trial.
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  Data: <searchLink fieldCode="AR" term="%22Nout%2C+R%2E+A%2E%22">Nout, R. A.</searchLink><br /><searchLink fieldCode="AR" term="%22Smit%2C+V%2E+T%2E+H%2E+B%2E+M%2E%22">Smit, V. T. H. B. M.</searchLink><br /><searchLink fieldCode="AR" term="%22Putter%2C+H%2E%22">Putter, H.</searchLink><br /><searchLink fieldCode="AR" term="%22Jürgenliemk-Schulz%2C+I%2E+M%2E%22">Jürgenliemk-Schulz, I. M.</searchLink><br /><searchLink fieldCode="AR" term="%22Jobsen%2C+J%2E+J%2E%22">Jobsen, J. J.</searchLink><br /><searchLink fieldCode="AR" term="%22Lutgens%2C+L%2E+C%2E+H%2E+W%2E%22">Lutgens, L. C. H. W.</searchLink><br /><searchLink fieldCode="AR" term="%22van+der+Steen-Banasik%2C+E%2E+M%2E%22">van der Steen-Banasik, E. M.</searchLink><br /><searchLink fieldCode="AR" term="%22Mens%2C+J%2E+W%2E+M%2E%22">Mens, J. W. M.</searchLink><br /><searchLink fieldCode="AR" term="%22Slot%2C+A%2E%22">Slot, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Stenfert+Kroese%2C+M%2E+C%2E%22">Stenfert Kroese, M. C.</searchLink><br /><searchLink fieldCode="AR" term="%22van+Bunningen%2C+B%2E+N%2E+F%2E+M%2E%22">van Bunningen, B. N. F. M.</searchLink><br /><searchLink fieldCode="AR" term="%22Ansink%2C+A%2E+C%2E%22">Ansink, A. C.</searchLink><br /><searchLink fieldCode="AR" term="%22van+Putten%2C+W%2E+U%2E%22">van Putten, W. U.</searchLink><br /><searchLink fieldCode="AR" term="%22Creutzberg%2C+C%2E+L%2E%22">Creutzberg, C. L.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Lancet%22">Lancet</searchLink>. 3/6/2010, Vol. 375 Issue 9717, p816-823. 8p. 4 Charts, 3 Graphs.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Vaginal+cancer%22">Vaginal cancer</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+treatment%22">Cancer treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Radioembolization%22">Radioembolization</searchLink><br /><searchLink fieldCode="DE" term="%22Radiotherapy%22">Radiotherapy</searchLink><br /><searchLink fieldCode="DE" term="%22Oncology+research%22">Oncology research</searchLink><br /><searchLink fieldCode="DE" term="%22Toxicity+testing%22">Toxicity testing</searchLink><br /><searchLink fieldCode="DE" term="%22Health+risk+assessment%22">Health risk assessment</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+relapse%22">Cancer relapse</searchLink><br /><searchLink fieldCode="DE" term="%22Endometrial+cancer%22">Endometrial cancer</searchLink><br /><searchLink fieldCode="DE" term="%22Endometrial+surgery%22">Endometrial surgery</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The article presents a study that compares the effectiveness of vaginal brachytherapy (VBT) and pelvic external beam radiotherapy (EBRT) in the prevention of vaginal recurrence after intermediate-risk endometrial carcinoma surgery. It states that the study is an open-label, non-inferiority, and randomized trial that was undertaken in 19 Dutch radiation oncology centers in which 427 patients with stage I or IIA endometrial carcinoma went through EBRT and VBT. The results showed that the rates of acute grade 1-2 gastrointestinal toxicity is lower in VBT group than the EBRT group. It concludes that VBT offers effective vaginal control with less gastrointestinal toxic effects.
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=48491188
RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1016/S0140-6736(09)62163-2
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      – Code: eng
        Text: English
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        StartPage: 816
    Subjects:
      – SubjectFull: Vaginal cancer
        Type: general
      – SubjectFull: Cancer treatment
        Type: general
      – SubjectFull: Radioembolization
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      – SubjectFull: Radiotherapy
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      – SubjectFull: Oncology research
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      – SubjectFull: Health risk assessment
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      – SubjectFull: Cancer relapse
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      – SubjectFull: Endometrial cancer
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      – SubjectFull: Endometrial surgery
        Type: general
    Titles:
      – TitleFull: Vaginal brachytherapy versus pelvic external beam radiotherapy for patients with endometrial cancer of high-intermediate risk (PORTEC-2): an open-label, non-inferiority, randomised trial.
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              Text: 3/6/2010
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