Eotaxin Synthesis by Nasal Polyp Fibroblasts.

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Bibliographic Details
Title:	Eotaxin Synthesis by Nasal Polyp Fibroblasts.
Authors:	Nonaka, Manabu, Pawankar, Ruby, Saji, Fusako, Yagi, Toshiaki
Source:	Acta Oto-Laryngologica. 12/30/99, Vol. 119 Issue 7, p816-820. 5p.
Subjects:	Nasal polyps, Fibroblasts, Endotoxins, Cytokines, Eosinophils
Abstract:	Nasal polyps is a chronic inflammatory disease of the upper airway characterized by structural abnormalities including stromal fibrosis. Fibroblasts are a rich source of cytokines and inflammatory mediators and are thought to play an important role in the development of fibrosis. In addition, there is considerable evidence for the participation of eosinophils in the pathophysiology of nasal polyps. Although increased numbers of eosinophils are present in nasal polyps, the mechanisms responsible for their selective accumulation are not completely clear. Eotaxin is a chemokine that promotes the selective recruitment of eosinophils. Thus, it may be an important molecule for the recruitment of eosinophils in nasal polyps. The purpose of this study was to investigate whether nasal polyp fibroblasts synthesize eotaxin after stimulation with lipopolysaccharide, IL-1β or TNF-α. Using primary nasal polyp tissue-derived fibroblast lines, we demonstrated that LPS, IL-1β and TNF-α induced the gene expression and protein production of eotaxin in nasal polyp fibroblasts. This responsiveness to LPS, IL-1β and TNF-α was time- and dose-dependent. These findings support the hypothesis that fibroblasts could play an important role in the recruitment of eosinophils in nasal polyps through the production of eotaxin. [ABSTRACT FROM AUTHOR]
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Database:	Psychology and Behavioral Sciences Collection

Description
Abstract:	Nasal polyps is a chronic inflammatory disease of the upper airway characterized by structural abnormalities including stromal fibrosis. Fibroblasts are a rich source of cytokines and inflammatory mediators and are thought to play an important role in the development of fibrosis. In addition, there is considerable evidence for the participation of eosinophils in the pathophysiology of nasal polyps. Although increased numbers of eosinophils are present in nasal polyps, the mechanisms responsible for their selective accumulation are not completely clear. Eotaxin is a chemokine that promotes the selective recruitment of eosinophils. Thus, it may be an important molecule for the recruitment of eosinophils in nasal polyps. The purpose of this study was to investigate whether nasal polyp fibroblasts synthesize eotaxin after stimulation with lipopolysaccharide, IL-1β or TNF-α. Using primary nasal polyp tissue-derived fibroblast lines, we demonstrated that LPS, IL-1β and TNF-α induced the gene expression and protein production of eotaxin in nasal polyp fibroblasts. This responsiveness to LPS, IL-1β and TNF-α was time- and dose-dependent. These findings support the hypothesis that fibroblasts could play an important role in the recruitment of eosinophils in nasal polyps through the production of eotaxin. [ABSTRACT FROM AUTHOR]
ISSN:	00016489
DOI:	10.1080/00016489950180478