Maturation of Schaffer collateral synapses generates a phenotype of unreliable basal evoked release and very reliable facilitated release.
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| Title: | Maturation of Schaffer collateral synapses generates a phenotype of unreliable basal evoked release and very reliable facilitated release. |
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| Authors: | Schiess, Adrian R. B. (AUTHOR), Scullin, Chessa (AUTHOR), Donald Partridge, L. (AUTHOR) |
| Source: | European Journal of Neuroscience. Apr2010, Vol. 31 Issue 8, p1377-1387. 11p. 7 Graphs. |
| Subjects: | Synapses, Phenotypes, Neuroplasticity, Nervous system, Hippocampus (Brain) |
| Abstract: | Short-term synaptic plasticity undergoes important age-dependent changes that have crucial implications during the development of the nervous system. Paired-pulse facilitation is a form of short-term synaptic plasticity by which the response to the second of two temporally-paired stimuli is larger and more reliable than the response to the first stimulus. In this study, a paired-pulse minimal stimulation technique was used to measure the probability and quantal amplitude of synaptic release at hippocampal synapses from 12–16-day-old (young) and 7–9-week-old (adult) rats. In order to assess the contribution of temperature-dependent processes, we carried out experiments at both room temperature and at near physiological temperature. We report here that neither temperature nor maturation affected the low basal evoked release probability and quantal amplitude of release. However, the warmer temperature revealed a unique developmental increase in facilitated evoked release probability and quantal amplitude of release. As a result, although both basal evoked release and facilitated release are rather unreliable in synapses from young animals, the maturation process at near physiological temperature generates a phenotype with unreliable basal evoked release and highly reliable facilitated release. [ABSTRACT FROM AUTHOR] |
| Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | Short-term synaptic plasticity undergoes important age-dependent changes that have crucial implications during the development of the nervous system. Paired-pulse facilitation is a form of short-term synaptic plasticity by which the response to the second of two temporally-paired stimuli is larger and more reliable than the response to the first stimulus. In this study, a paired-pulse minimal stimulation technique was used to measure the probability and quantal amplitude of synaptic release at hippocampal synapses from 12–16-day-old (young) and 7–9-week-old (adult) rats. In order to assess the contribution of temperature-dependent processes, we carried out experiments at both room temperature and at near physiological temperature. We report here that neither temperature nor maturation affected the low basal evoked release probability and quantal amplitude of release. However, the warmer temperature revealed a unique developmental increase in facilitated evoked release probability and quantal amplitude of release. As a result, although both basal evoked release and facilitated release are rather unreliable in synapses from young animals, the maturation process at near physiological temperature generates a phenotype with unreliable basal evoked release and highly reliable facilitated release. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 0953816X |
| DOI: | 10.1111/j.1460-9568.2010.07180.x |
