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An early improvement threshold to predict response and remission in first-episode schizophrenia.

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Bibliographic Details
Title:	An early improvement threshold to predict response and remission in first-episode schizophrenia.
Authors:	Schennach-Wolff, R., Seemüller, F. H., Mayr, A., Maier, W., Klingberg, S., Heuser, I., Klosterkötter, J., Gastpar, M., Häfner, H., Sauer, H., Schneider, F., Gaebel, W., Jäger, M., Möller, H.-J., Riedel, M., Schennach-Wolff, Rebecca (AUTHOR), Seemüller, Florian Hannes (AUTHOR), Mayr, Andreas (AUTHOR), Maier, Wolfgang (AUTHOR), Klingberg, Stefan (AUTHOR)
Source:	British Journal of Psychiatry. Jun2010, Vol. 196 Issue 6, p460-466. 7p. 2 Diagrams, 3 Charts, 4 Graphs.
Subjects:	Schizophrenia, Syndromes, Etiology of diseases, Psychotherapy patients, Pathological psychology
Abstract:	Background: Early improvement with treatment is thought to be important in patients with first-episode schizophrenia, yet a valid definition is still outstanding.Aims: To develop a valid definition of early improvement and test its predictive validity regarding response and remission.Method: We examined 188 in-patients with first-episode schizophrenia. Early improvement was defined as improvement in Positive and Negative Syndrome Scale (PANSS) total score at week 2, response as a 40% PANSS total score improvement at end-point, and remission according to consensus criteria.Results: Reasonable predictive validity of early improvement was found for a 46% PANSS total score improvement at week 2 and a 50% improvement for remission (area under the curve: response 0.707, remission 0.692). Estimated confidence intervals ranged from 26 to 62% PANSS reduction for response and remission.Conclusions: Patients with a first episode of schizophrenia should improve by at least 30% in PANSS total score at week 2 to achieve response and remission. [ABSTRACT FROM AUTHOR]
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Database:	Psychology and Behavioral Sciences Collection

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