Forelimb dyskinesia mediated by high-frequency stimulation of the subthalamic nucleus is linked to rapid activation of the NR2B subunit of N-methyl-d-aspartate receptors.
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| Title: | Forelimb dyskinesia mediated by high-frequency stimulation of the subthalamic nucleus is linked to rapid activation of the NR2B subunit of N-methyl-d-aspartate receptors. |
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| Authors: | Quintana, Adrien (AUTHOR), Melon, Christophe (AUTHOR), Goff, Lydia Kerkerian‐Le (AUTHOR), Salin, Pascal (AUTHOR), Savasta, Marc (AUTHOR), Sgambato‐Faure, Véronique (AUTHOR) |
| Source: | European Journal of Neuroscience. Aug2010, Vol. 32 Issue 3, p423-434. 12p. 6 Graphs. |
| Subjects: | Movement disorders, Dopa, Parkinson's disease, Methyl aspartate, Catecholamines, Subthalamic nucleus |
| Abstract: | Dyskinesia is a major side-effect of chronicl-DOPA administration, the reference treatment for Parkinson’s disease. High-frequency stimulation of the subthalamic nucleus (STN-HFS) alleviates parkinsonian motor symptoms and indirectly improves dyskinesia by decreasing thel-DOPA requirement. However, inappropriate stimulation can also trigger dyskinetic movements, in both human and rodents. We investigated whether STN-HFS-evoked forelimb dyskinesia involved changes in glutamatergic neurotransmission as previously reported forl-DOPA-induced dyskinesias, focusing on the role of NR2B-containing N-methyl-d-aspartate receptors (NR2B/NMDARs). We applied STN-HFS in normal rats at intensities above and below the threshold for triggering forelimb dyskinesia. Dyskinesiogenic STN-HFS induced the activation of NR2B (as assessed by immunodetection of the phosphorylated residue Tyr1472) in neurons of the subthalamic nucleus, entopeduncular nucleus, motor thalamus and forelimb motor cortex. The severity of STN-HFS-induced forelimb dyskinesia was decreased in a dose-dependent manner by systemic injections of CP-101,606, a selective blocker of NR2B/NMDARs, but was either unaffected or increased by the non-selective N-methyl-d-aspartate receptor antagonist, MK-801. [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | Dyskinesia is a major side-effect of chronicl-DOPA administration, the reference treatment for Parkinson’s disease. High-frequency stimulation of the subthalamic nucleus (STN-HFS) alleviates parkinsonian motor symptoms and indirectly improves dyskinesia by decreasing thel-DOPA requirement. However, inappropriate stimulation can also trigger dyskinetic movements, in both human and rodents. We investigated whether STN-HFS-evoked forelimb dyskinesia involved changes in glutamatergic neurotransmission as previously reported forl-DOPA-induced dyskinesias, focusing on the role of NR2B-containing N-methyl-d-aspartate receptors (NR2B/NMDARs). We applied STN-HFS in normal rats at intensities above and below the threshold for triggering forelimb dyskinesia. Dyskinesiogenic STN-HFS induced the activation of NR2B (as assessed by immunodetection of the phosphorylated residue Tyr1472) in neurons of the subthalamic nucleus, entopeduncular nucleus, motor thalamus and forelimb motor cortex. The severity of STN-HFS-induced forelimb dyskinesia was decreased in a dose-dependent manner by systemic injections of CP-101,606, a selective blocker of NR2B/NMDARs, but was either unaffected or increased by the non-selective N-methyl-d-aspartate receptor antagonist, MK-801. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 0953816X |
| DOI: | 10.1111/j.1460-9568.2010.07290.x |
