Bibliographic Details
| Title: |
The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease. |
| Authors: |
Cookson, Mark R. |
| Source: |
Nature Reviews Neuroscience. Dec2010, Vol. 11 Issue 12, p791-797. 7p. 2 Diagrams. |
| Subjects: |
Leucine, Parkinson's disease & genetics, Physiological effects of proteins, Genetic mutation, Guanosine triphosphatase, Biological models, Central nervous system, Disease susceptibility, Dopamine, Nerve tissue proteins, Parkinson's disease, Transferases |
| Abstract: |
Parkinson's disease, like many common age-related conditions, is now recognized to have a substantial genetic component. Here, I discuss how mutations in a large complex gene--leucine-rich repeat kinase 2 (LRRK2)--affect protein function, and I review recent evidence that LRRK2 mutations affect pathways that involve other proteins that have been implicated in Parkinson's disease, specifically α-synuclein and tau. These concepts can be used to understand disease processes and to develop therapeutic opportunities for the treatment of Parkinson's disease. [ABSTRACT FROM AUTHOR] |
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| Database: |
Psychology and Behavioral Sciences Collection |
