Effects of traumatic brain injury on cognitive functioning and cerebral metabolites in HIV-infected individuals.
Saved in:
| Title: | Effects of traumatic brain injury on cognitive functioning and cerebral metabolites in HIV-infected individuals. |
|---|---|
| Authors: | Lin, Kenny (AUTHOR), Taylor, MichaelJ (AUTHOR), Heaton, Robert (AUTHOR), Franklin, Donald (AUTHOR), Jernigan, Terry (AUTHOR), Fennema-Notestine, Christine (AUTHOR), McCutchan, Allen (AUTHOR), Atkinson, JHampton (AUTHOR), Ellis, RonaldJ (AUTHOR), McArthur, Justin (AUTHOR), Morgello, Susan (AUTHOR), Simpson, David (AUTHOR), Collier, AnnC (AUTHOR), Marra, Christina (AUTHOR), Gelman, Benjamin (AUTHOR), Clifford, David (AUTHOR), Grant, Igor (AUTHOR), for the CHARTER group (AUTHOR) |
| Source: | Journal of Clinical & Experimental Neuropsychology. Mar2011, Vol. 33 Issue 3, p326-334. 9p. 5 Charts. |
| Subjects: | Brain injuries, Metabolites, HIV-positive persons, Cognition disorders, Magnetic resonance, HIV infections |
| Abstract: | We explored the possible augmenting effect of traumatic brain injury (TBI) history on HIV (human immunodeficiency virus) associated neurocognitive complications. HIV-infected participants with self-reported history of definite TBI were compared to HIV patients without TBI history. Groups were equated for relevant demographic and HIV-associated characteristics. The TBI group evidenced significantly greater deficits in executive functioning and working memory. N-acetylaspartate, a putative marker of neuronal integrity, was significantly lower in the frontal gray matter and basal ganglia brain regions of the TBI group. Together, these results suggest an additional brain impact of TBI over that from HIV alone. One clinical implication is that HIV patients with TBI history may need to be monitored more closely for increased risk of HIV-associated neurocognitive disorder signs or symptoms. [ABSTRACT FROM AUTHOR] |
| Copyright of Journal of Clinical & Experimental Neuropsychology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
|
Full text is not displayed to guests.
Login for full access.
|
|
| Abstract: | We explored the possible augmenting effect of traumatic brain injury (TBI) history on HIV (human immunodeficiency virus) associated neurocognitive complications. HIV-infected participants with self-reported history of definite TBI were compared to HIV patients without TBI history. Groups were equated for relevant demographic and HIV-associated characteristics. The TBI group evidenced significantly greater deficits in executive functioning and working memory. N-acetylaspartate, a putative marker of neuronal integrity, was significantly lower in the frontal gray matter and basal ganglia brain regions of the TBI group. Together, these results suggest an additional brain impact of TBI over that from HIV alone. One clinical implication is that HIV patients with TBI history may need to be monitored more closely for increased risk of HIV-associated neurocognitive disorder signs or symptoms. [ABSTRACT FROM AUTHOR] |
|---|---|
| ISSN: | 13803395 |
| DOI: | 10.1080/13803395.2010.518140 |
