Antipsychotic prophylaxis is needed after remission from a first psychotic episode in schizophrenia patients: Results from an aborted randomised trial.
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| Title: | Antipsychotic prophylaxis is needed after remission from a first psychotic episode in schizophrenia patients: Results from an aborted randomised trial. |
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| Authors: | Boonstra, Geartsje (AUTHOR), Burger, Huibert (AUTHOR), Grobbee, Diederick E (AUTHOR), Kahn, René S (AUTHOR) |
| Source: | International Journal of Psychiatry in Clinical Practice. Jun2011, Vol. 15 Issue 2, p128-134. 7p. |
| Subjects: | Analysis of variance, Antipsychotic agents, Confidence intervals, Probability theory, Research funding, Schizophrenia, Survival analysis (Biometry), Secondary analysis, Randomized controlled trials, Disease remission |
| Abstract: | Objective. To assess the effect of withdrawal of antipsychotic treatment on relapse risk in remitted first-episode schizophrenia patients. Methods. First-episode 1-year stable and remitted outpatients with a schizophrenic disorder were randomly allocated to continuation of their antipsychotic regimen for at least 6 months ( N == 9), or gradual withdrawal ( N == 11). Primary outcome was the difference in cumulative relapse-free survival at 9 months. Results. Recruitment was terminated prematurely on 26 October 2005. The cumulative relapse-free survival was 88% (SE == 0.12) in the continuation and 18% (SE == 0.12) in the discontinuation group ( P == 0.001) at 9 months follow-up. Conclusions. Discontinuation of antipsychotic medication markedly increases the risk of relapse in stable remitted first-episode schizophrenia patients. In future studies the topics of safety monitoring and sampling of patients should receive extra attention. [ABSTRACT FROM AUTHOR] |
| Copyright of International Journal of Psychiatry in Clinical Practice is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | Objective. To assess the effect of withdrawal of antipsychotic treatment on relapse risk in remitted first-episode schizophrenia patients. Methods. First-episode 1-year stable and remitted outpatients with a schizophrenic disorder were randomly allocated to continuation of their antipsychotic regimen for at least 6 months ( N == 9), or gradual withdrawal ( N == 11). Primary outcome was the difference in cumulative relapse-free survival at 9 months. Results. Recruitment was terminated prematurely on 26 October 2005. The cumulative relapse-free survival was 88% (SE == 0.12) in the continuation and 18% (SE == 0.12) in the discontinuation group ( P == 0.001) at 9 months follow-up. Conclusions. Discontinuation of antipsychotic medication markedly increases the risk of relapse in stable remitted first-episode schizophrenia patients. In future studies the topics of safety monitoring and sampling of patients should receive extra attention. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 13651501 |
| DOI: | 10.3109/13651501.2010.534801 |
