Fatal allergic vasculitis associated with celecoxib.
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| Title: | Fatal allergic vasculitis associated with celecoxib. |
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| Authors: | Schneider, F, Meziani, F, Chartier, C, Alt, M, Jaeger, A |
| Source: | Lancet. 3/9/2002, Vol. 359 Issue 9309, p852. 2p. 1 Color Photograph. |
| Subjects: | Celecoxib, Drug side effects, Multiple organ failure, Thrombosis risk factors |
| Abstract: | We report on the occurrence of a rare and as yet unforseeable adverse reaction to treatment with celecoxib, a cyclooxygenase-2 (COX-2) selective, non-steroidal, anti-inflammatory drug. A previously healthy adult suffered fatal acute multiple organ failure presumably after diffuse allergic vasculitis with diffuse necrotic purpura. Although no conclusive proof is available, such a reaction could have been triggered by at least one of two mechanisms: an allergic reaction linked to the chemical structure of celecoxib; or an interaction of the drug with synthesis of endothelial eiconasoids leading to an imbalance between vasoactive end products, resulting in widespread rise to local thrombosis. [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | We report on the occurrence of a rare and as yet unforseeable adverse reaction to treatment with celecoxib, a cyclooxygenase-2 (COX-2) selective, non-steroidal, anti-inflammatory drug. A previously healthy adult suffered fatal acute multiple organ failure presumably after diffuse allergic vasculitis with diffuse necrotic purpura. Although no conclusive proof is available, such a reaction could have been triggered by at least one of two mechanisms: an allergic reaction linked to the chemical structure of celecoxib; or an interaction of the drug with synthesis of endothelial eiconasoids leading to an imbalance between vasoactive end products, resulting in widespread rise to local thrombosis. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 01406736 |
| DOI: | 10.1016/S0140-6736(02)07922-9 |
