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Fatal allergic vasculitis associated with celecoxib.

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Title: Fatal allergic vasculitis associated with celecoxib.
Authors: Schneider, F, Meziani, F, Chartier, C, Alt, M, Jaeger, A
Source: Lancet. 3/9/2002, Vol. 359 Issue 9309, p852. 2p. 1 Color Photograph.
Subjects: Celecoxib, Drug side effects, Multiple organ failure, Thrombosis risk factors
Abstract: We report on the occurrence of a rare and as yet unforseeable adverse reaction to treatment with celecoxib, a cyclooxygenase-2 (COX-2) selective, non-steroidal, anti-inflammatory drug. A previously healthy adult suffered fatal acute multiple organ failure presumably after diffuse allergic vasculitis with diffuse necrotic purpura. Although no conclusive proof is available, such a reaction could have been triggered by at least one of two mechanisms: an allergic reaction linked to the chemical structure of celecoxib; or an interaction of the drug with synthesis of endothelial eiconasoids leading to an imbalance between vasoactive end products, resulting in widespread rise to local thrombosis. [ABSTRACT FROM AUTHOR]
Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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PubType: Academic Journal
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  Data: Fatal allergic vasculitis associated with celecoxib.
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  Data: <searchLink fieldCode="AR" term="%22Schneider%2C+F%22">Schneider, F</searchLink><br /><searchLink fieldCode="AR" term="%22Meziani%2C+F%22">Meziani, F</searchLink><br /><searchLink fieldCode="AR" term="%22Chartier%2C+C%22">Chartier, C</searchLink><br /><searchLink fieldCode="AR" term="%22Alt%2C+M%22">Alt, M</searchLink><br /><searchLink fieldCode="AR" term="%22Jaeger%2C+A%22">Jaeger, A</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Lancet%22">Lancet</searchLink>. 3/9/2002, Vol. 359 Issue 9309, p852. 2p. 1 Color Photograph.
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  Data: <searchLink fieldCode="DE" term="%22Celecoxib%22">Celecoxib</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+side+effects%22">Drug side effects</searchLink><br /><searchLink fieldCode="DE" term="%22Multiple+organ+failure%22">Multiple organ failure</searchLink><br /><searchLink fieldCode="DE" term="%22Thrombosis+risk+factors%22">Thrombosis risk factors</searchLink>
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  Data: We report on the occurrence of a rare and as yet unforseeable adverse reaction to treatment with celecoxib, a cyclooxygenase-2 (COX-2) selective, non-steroidal, anti-inflammatory drug. A previously healthy adult suffered fatal acute multiple organ failure presumably after diffuse allergic vasculitis with diffuse necrotic purpura. Although no conclusive proof is available, such a reaction could have been triggered by at least one of two mechanisms: an allergic reaction linked to the chemical structure of celecoxib; or an interaction of the drug with synthesis of endothelial eiconasoids leading to an imbalance between vasoactive end products, resulting in widespread rise to local thrombosis. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1016/S0140-6736(02)07922-9
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      – Code: eng
        Text: English
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      – SubjectFull: Celecoxib
        Type: general
      – SubjectFull: Drug side effects
        Type: general
      – SubjectFull: Multiple organ failure
        Type: general
      – SubjectFull: Thrombosis risk factors
        Type: general
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      – TitleFull: Fatal allergic vasculitis associated with celecoxib.
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            NameFull: Schneider, F
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              M: 03
              Text: 3/9/2002
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              Y: 2002
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              Value: 359
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