Association of Angiotensin-Converting Enzyme Insertion(I)/Deletion (D) Genotype in Alzheimer's Disease Patients of North Indian Population.
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| Title: | Association of Angiotensin-Converting Enzyme Insertion(I)/Deletion (D) Genotype in Alzheimer's Disease Patients of North Indian Population. |
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| Authors: | Nirmal, Sonali (AUTHOR), Tripathi, Manjari (AUTHOR), Shastri, Shivaram S. (AUTHOR), Sagar, Rajesh (AUTHOR), S., Vivekanandhan (AUTHOR) |
| Source: | International Journal of Neuroscience. Oct2011, Vol. 121 Issue 10, p557-561. 5p. 2 Black and White Photographs, 3 Charts. |
| Subjects: | Angiotensin converting enzyme, Genetic polymorphisms, Alzheimer's patients, Human genetics, Control groups, Cognition disorder risk factors, Serum |
| Geographic Terms: | India |
| Abstract: | Several lines of evidence support for the role of angiotensin-converting enzyme (ACE) in Alzheimer's disease (AD) patients. Most human genetic studies have focussed on ACE insertion (I)/deletion (D) polymorphism and have yielded conflicting results. We have evaluated the association of ACE polymorphism with serum ACE activity in 95 AD patients and 110 healthy controls from north Indian population. In Alzheimer's patients a higher frequency of D allele was detected (I/D ratio 0.53:0.47) compared with the control group (I/D ratio 0.54:0.45), the difference being not statistically significant ( p > .05). AD patients were found to be more homozygous for the D allele (26.3%%) compared with controls (20.8%%). The observed genotype distribution was in agreement with Hardy- Weinberg equilibrium. We observed that the D/D genotype is more in patients with a higher serum ACE activity. The D allele and the D/D genotype in AD patients may influence increased risk of cognitive impairment. [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | Several lines of evidence support for the role of angiotensin-converting enzyme (ACE) in Alzheimer's disease (AD) patients. Most human genetic studies have focussed on ACE insertion (I)/deletion (D) polymorphism and have yielded conflicting results. We have evaluated the association of ACE polymorphism with serum ACE activity in 95 AD patients and 110 healthy controls from north Indian population. In Alzheimer's patients a higher frequency of D allele was detected (I/D ratio 0.53:0.47) compared with the control group (I/D ratio 0.54:0.45), the difference being not statistically significant ( p > .05). AD patients were found to be more homozygous for the D allele (26.3%%) compared with controls (20.8%%). The observed genotype distribution was in agreement with Hardy- Weinberg equilibrium. We observed that the D/D genotype is more in patients with a higher serum ACE activity. The D allele and the D/D genotype in AD patients may influence increased risk of cognitive impairment. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 00207454 |
| DOI: | 10.3109/00207454.2011.591513 |
