Association of Angiotensin-Converting Enzyme Insertion(I)/Deletion (D) Genotype in Alzheimer's Disease Patients of North Indian Population.
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| Title: | Association of Angiotensin-Converting Enzyme Insertion(I)/Deletion (D) Genotype in Alzheimer's Disease Patients of North Indian Population. |
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| Authors: | Nirmal, Sonali (AUTHOR), Tripathi, Manjari (AUTHOR), Shastri, Shivaram S. (AUTHOR), Sagar, Rajesh (AUTHOR), S., Vivekanandhan (AUTHOR) |
| Source: | International Journal of Neuroscience. Oct2011, Vol. 121 Issue 10, p557-561. 5p. 2 Black and White Photographs, 3 Charts. |
| Subjects: | Angiotensin converting enzyme, Genetic polymorphisms, Alzheimer's patients, Human genetics, Control groups, Cognition disorder risk factors, Serum |
| Geographic Terms: | India |
| Abstract: | Several lines of evidence support for the role of angiotensin-converting enzyme (ACE) in Alzheimer's disease (AD) patients. Most human genetic studies have focussed on ACE insertion (I)/deletion (D) polymorphism and have yielded conflicting results. We have evaluated the association of ACE polymorphism with serum ACE activity in 95 AD patients and 110 healthy controls from north Indian population. In Alzheimer's patients a higher frequency of D allele was detected (I/D ratio 0.53:0.47) compared with the control group (I/D ratio 0.54:0.45), the difference being not statistically significant ( p > .05). AD patients were found to be more homozygous for the D allele (26.3%%) compared with controls (20.8%%). The observed genotype distribution was in agreement with Hardy- Weinberg equilibrium. We observed that the D/D genotype is more in patients with a higher serum ACE activity. The D allele and the D/D genotype in AD patients may influence increased risk of cognitive impairment. [ABSTRACT FROM AUTHOR] |
| Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 65801767 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Association of Angiotensin-Converting Enzyme Insertion(I)/Deletion (D) Genotype in Alzheimer's Disease Patients of North Indian Population. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Nirmal%2C+Sonali%22">Nirmal, Sonali</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tripathi%2C+Manjari%22">Tripathi, Manjari</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shastri%2C+Shivaram+S%2E%22">Shastri, Shivaram S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sagar%2C+Rajesh%22">Sagar, Rajesh</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22S%2E%2C+Vivekanandhan%22">S., Vivekanandhan</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Neuroscience%22">International Journal of Neuroscience</searchLink>. Oct2011, Vol. 121 Issue 10, p557-561. 5p. 2 Black and White Photographs, 3 Charts. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Angiotensin+converting+enzyme%22">Angiotensin converting enzyme</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+polymorphisms%22">Genetic polymorphisms</searchLink><br /><searchLink fieldCode="DE" term="%22Alzheimer's+patients%22">Alzheimer's patients</searchLink><br /><searchLink fieldCode="DE" term="%22Human+genetics%22">Human genetics</searchLink><br /><searchLink fieldCode="DE" term="%22Control+groups%22">Control groups</searchLink><br /><searchLink fieldCode="DE" term="%22Cognition+disorder+risk+factors%22">Cognition disorder risk factors</searchLink><br /><searchLink fieldCode="DE" term="%22Serum%22">Serum</searchLink> – Name: SubjectGeographic Label: Geographic Terms Group: Su Data: <searchLink fieldCode="DE" term="%22India%22">India</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Several lines of evidence support for the role of angiotensin-converting enzyme (ACE) in Alzheimer's disease (AD) patients. Most human genetic studies have focussed on ACE insertion (I)/deletion (D) polymorphism and have yielded conflicting results. We have evaluated the association of ACE polymorphism with serum ACE activity in 95 AD patients and 110 healthy controls from north Indian population. In Alzheimer's patients a higher frequency of D allele was detected (I/D ratio 0.53:0.47) compared with the control group (I/D ratio 0.54:0.45), the difference being not statistically significant ( p > .05). AD patients were found to be more homozygous for the D allele (26.3%%) compared with controls (20.8%%). The observed genotype distribution was in agreement with Hardy- Weinberg equilibrium. We observed that the D/D genotype is more in patients with a higher serum ACE activity. The D allele and the D/D genotype in AD patients may influence increased risk of cognitive impairment. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=65801767 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3109/00207454.2011.591513 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 5 StartPage: 557 Subjects: – SubjectFull: Angiotensin converting enzyme Type: general – SubjectFull: Genetic polymorphisms Type: general – SubjectFull: Alzheimer's patients Type: general – SubjectFull: Human genetics Type: general – SubjectFull: Control groups Type: general – SubjectFull: Cognition disorder risk factors Type: general – SubjectFull: Serum Type: general – SubjectFull: India Type: general Titles: – TitleFull: Association of Angiotensin-Converting Enzyme Insertion(I)/Deletion (D) Genotype in Alzheimer's Disease Patients of North Indian Population. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Nirmal, Sonali – PersonEntity: Name: NameFull: Tripathi, Manjari – PersonEntity: Name: NameFull: Shastri, Shivaram S. – PersonEntity: Name: NameFull: Sagar, Rajesh – PersonEntity: Name: NameFull: S., Vivekanandhan IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 10 Text: Oct2011 Type: published Y: 2011 Identifiers: – Type: issn-print Value: 00207454 Numbering: – Type: volume Value: 121 – Type: issue Value: 10 Titles: – TitleFull: International Journal of Neuroscience Type: main |
| ResultId | 1 |
