Neurochemical and behavioural characterization of milnacipran, a serotonin and noradrenaline reuptake inhibitor in rats.

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Bibliographic Details
Title:	Neurochemical and behavioural characterization of milnacipran, a serotonin and noradrenaline reuptake inhibitor in rats.
Authors:	Mochizuki, Daisuke, Tsujita, Ryuichi, Yamada, Shinji, Kawasaki, Koh, Otsuka, Yuji, Hashimoto, Shinji, Hattori, Tsuyoshi, Kitamura, Yoshihisa, Miki, Naomasa
Source:	Psychopharmacology. 2002, Vol. 162 Issue 3, p323. 10p. 5 Charts, 5 Graphs.
Subjects:	Chemical inhibitors, Antidepressants, Animal behavior, Pharmacodynamics
Abstract:	Presents a study aimed at characterizing neurochemically and behaviorally the serotonin and noradrenaline reuptake inhibitor (SNRI), milnacipran, in the prefrontal cortex in comparison with tricyclic antidepressants and selective serotonin reuptake inhibitors. Methods; Results; Conclusion that milnacipran significantly reduced the duration of both the immobility time in a forced swimming test and the freezing time in a conditioned fear stress test in rats.
Database:	Psychology and Behavioral Sciences Collection

Description
Abstract:	Presents a study aimed at characterizing neurochemically and behaviorally the serotonin and noradrenaline reuptake inhibitor (SNRI), milnacipran, in the prefrontal cortex in comparison with tricyclic antidepressants and selective serotonin reuptake inhibitors. Methods; Results; Conclusion that milnacipran significantly reduced the duration of both the immobility time in a forced swimming test and the freezing time in a conditioned fear stress test in rats.
ISSN:	00333158
DOI:	10.1007/s00213-002-1111-5