Bibliographic Details
| Title: |
A Major Genome Region Underlying Artemisinin Resistance in Malaria. |
| Authors: |
Cheeseman, Ian H., Miller, Becky A., Nair, Shalini, Nkhoma, Standwell, Tan, Asako, Tan, John C., Al Saai, Salma, Aung Pyae Phyo, Carit Ler Moo, Khin Maung Lwin, McGready, Rose, Ashley, Elizabeth, Imwong, Mallika, Stepniewska, Kasia, Yi, Poravuth, Dondorp, Arjen M., Mayxay, Mayfong, Newton, Paul N., White, Nicholas J., Nosten, Francois |
| Source: |
Science (pre-March 2025). 4/6/2012, Vol. 336 Issue 6077, p79-82. 4p. |
| Subjects: |
Artemisinin, Drug resistance, Malaria prevention, Molecular parasitology, Single nucleotide polymorphisms, Microsatellite repeats, Vicariance, Haplotypes, Protozoa |
| Abstract: |
Evolving resistance to artemisinin-based compounds threatens to derail attempts to control malaria. Resistance has been confirmed in western Cambodia and has recently emerged in western Thailand, but is absent from neighboring Laos. Artemisinin resistance results in reduced parasite clearance rates (CRs) after treatment. We used a two-phase strategy to identify genome region(s) underlying this ongoing selective event. Geographical differentiation and haplotype structure at 6969 polymorphic single-nucleotide polymorphisms (SNPs) in 91 parasites from Cambodia, Thailand, and Laos identified 33 genome regions under strong selection. We screened SNPs and microsatellites within these regions in 715 parasites from Thailand, identifying a selective sweep on chromosome 13 that shows strong association (P = 10-6 to 10-12) with slow ORs, illustrating the efficacy of targeted association for identifying the genetic basis of adaptive traits. [ABSTRACT FROM AUTHOR] |
|
Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Psychology and Behavioral Sciences Collection |
