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A Major Genome Region Underlying Artemisinin Resistance in Malaria.

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Title: A Major Genome Region Underlying Artemisinin Resistance in Malaria.
Authors: Cheeseman, Ian H., Miller, Becky A., Nair, Shalini, Nkhoma, Standwell, Tan, Asako, Tan, John C., Al Saai, Salma, Aung Pyae Phyo, Carit Ler Moo, Khin Maung Lwin, McGready, Rose, Ashley, Elizabeth, Imwong, Mallika, Stepniewska, Kasia, Yi, Poravuth, Dondorp, Arjen M., Mayxay, Mayfong, Newton, Paul N., White, Nicholas J., Nosten, Francois
Source: Science (pre-March 2025). 4/6/2012, Vol. 336 Issue 6077, p79-82. 4p.
Subjects: Artemisinin, Drug resistance, Malaria prevention, Molecular parasitology, Single nucleotide polymorphisms, Microsatellite repeats, Vicariance, Haplotypes, Protozoa
Abstract: Evolving resistance to artemisinin-based compounds threatens to derail attempts to control malaria. Resistance has been confirmed in western Cambodia and has recently emerged in western Thailand, but is absent from neighboring Laos. Artemisinin resistance results in reduced parasite clearance rates (CRs) after treatment. We used a two-phase strategy to identify genome region(s) underlying this ongoing selective event. Geographical differentiation and haplotype structure at 6969 polymorphic single-nucleotide polymorphisms (SNPs) in 91 parasites from Cambodia, Thailand, and Laos identified 33 genome regions under strong selection. We screened SNPs and microsatellites within these regions in 715 parasites from Thailand, identifying a selective sweep on chromosome 13 that shows strong association (P = 10-6 to 10-12) with slow ORs, illustrating the efficacy of targeted association for identifying the genetic basis of adaptive traits. [ABSTRACT FROM AUTHOR]
Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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DbLabel: Psychology and Behavioral Sciences Collection
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PubType: Academic Journal
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  Data: A Major Genome Region Underlying Artemisinin Resistance in Malaria.
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  Data: <searchLink fieldCode="AR" term="%22Cheeseman%2C+Ian+H%2E%22">Cheeseman, Ian H.</searchLink><br /><searchLink fieldCode="AR" term="%22Miller%2C+Becky+A%2E%22">Miller, Becky A.</searchLink><br /><searchLink fieldCode="AR" term="%22Nair%2C+Shalini%22">Nair, Shalini</searchLink><br /><searchLink fieldCode="AR" term="%22Nkhoma%2C+Standwell%22">Nkhoma, Standwell</searchLink><br /><searchLink fieldCode="AR" term="%22Tan%2C+Asako%22">Tan, Asako</searchLink><br /><searchLink fieldCode="AR" term="%22Tan%2C+John+C%2E%22">Tan, John C.</searchLink><br /><searchLink fieldCode="AR" term="%22Al+Saai%2C+Salma%22">Al Saai, Salma</searchLink><br /><searchLink fieldCode="AR" term="%22Aung+Pyae+Phyo%22">Aung Pyae Phyo</searchLink><br /><searchLink fieldCode="AR" term="%22Carit+Ler+Moo%22">Carit Ler Moo</searchLink><br /><searchLink fieldCode="AR" term="%22Khin+Maung+Lwin%22">Khin Maung Lwin</searchLink><br /><searchLink fieldCode="AR" term="%22McGready%2C+Rose%22">McGready, Rose</searchLink><br /><searchLink fieldCode="AR" term="%22Ashley%2C+Elizabeth%22">Ashley, Elizabeth</searchLink><br /><searchLink fieldCode="AR" term="%22Imwong%2C+Mallika%22">Imwong, Mallika</searchLink><br /><searchLink fieldCode="AR" term="%22Stepniewska%2C+Kasia%22">Stepniewska, Kasia</searchLink><br /><searchLink fieldCode="AR" term="%22Yi%2C+Poravuth%22">Yi, Poravuth</searchLink><br /><searchLink fieldCode="AR" term="%22Dondorp%2C+Arjen+M%2E%22">Dondorp, Arjen M.</searchLink><br /><searchLink fieldCode="AR" term="%22Mayxay%2C+Mayfong%22">Mayxay, Mayfong</searchLink><br /><searchLink fieldCode="AR" term="%22Newton%2C+Paul+N%2E%22">Newton, Paul N.</searchLink><br /><searchLink fieldCode="AR" term="%22White%2C+Nicholas+J%2E%22">White, Nicholas J.</searchLink><br /><searchLink fieldCode="AR" term="%22Nosten%2C+Francois%22">Nosten, Francois</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 4/6/2012, Vol. 336 Issue 6077, p79-82. 4p.
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  Data: <searchLink fieldCode="DE" term="%22Artemisinin%22">Artemisinin</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+resistance%22">Drug resistance</searchLink><br /><searchLink fieldCode="DE" term="%22Malaria+prevention%22">Malaria prevention</searchLink><br /><searchLink fieldCode="DE" term="%22Molecular+parasitology%22">Molecular parasitology</searchLink><br /><searchLink fieldCode="DE" term="%22Single+nucleotide+polymorphisms%22">Single nucleotide polymorphisms</searchLink><br /><searchLink fieldCode="DE" term="%22Microsatellite+repeats%22">Microsatellite repeats</searchLink><br /><searchLink fieldCode="DE" term="%22Vicariance%22">Vicariance</searchLink><br /><searchLink fieldCode="DE" term="%22Haplotypes%22">Haplotypes</searchLink><br /><searchLink fieldCode="DE" term="%22Protozoa%22">Protozoa</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Evolving resistance to artemisinin-based compounds threatens to derail attempts to control malaria. Resistance has been confirmed in western Cambodia and has recently emerged in western Thailand, but is absent from neighboring Laos. Artemisinin resistance results in reduced parasite clearance rates (CRs) after treatment. We used a two-phase strategy to identify genome region(s) underlying this ongoing selective event. Geographical differentiation and haplotype structure at 6969 polymorphic single-nucleotide polymorphisms (SNPs) in 91 parasites from Cambodia, Thailand, and Laos identified 33 genome regions under strong selection. We screened SNPs and microsatellites within these regions in 715 parasites from Thailand, identifying a selective sweep on chromosome 13 that shows strong association (P = 10-6 to 10-12) with slow ORs, illustrating the efficacy of targeted association for identifying the genetic basis of adaptive traits. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=74730957
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        Value: 10.1126/science.1215966
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        Text: English
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      – SubjectFull: Artemisinin
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