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Emergence of artemisinin-resistant malaria on the western border of Thailand: a longitudinal study.

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Title: Emergence of artemisinin-resistant malaria on the western border of Thailand: a longitudinal study.
Authors: Aung Pyae Phyo, Nkhoma, Standwell, Stepniewska, Kasia, Ashley, Elizabeth A., Nair, Shalini, McGready, Rose, Moo, Carit ler, Al-Saai, Salma, Dondorp, Arjen M., Lwin, Khin Maung, Singhasivanon, Pratap, Day, Nicholas P. J., White, Nicholas J., Anderson, Tim J. C., Nosten, François
Source: Lancet. 5/26/2012, Vol. 379 Issue 9830, p1960-1966. 7p.
Subjects: Medical research, Artemisinin, Parasites, Plasmodium falciparum
Geographic Terms: Myanmar, Thailand
Abstract: The article presents a study that establishes whether artemisinin resistance has spread on the Thailand-Burma border. It shows that parasite clearance half-lives lengthened from a geometric mean of 6.2 hours in 2001 to 3.7 hours in 2010. It indicates that the proportion of slow-clearing infections has increased from 0.6% in 2011 to 20% in 2010. It reveals that genetically determined artemisinin resistance in Plasmodium falciparum emerged along the border at least eight years ago.
Database: Psychology and Behavioral Sciences Collection
FullText Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 76277088
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
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  Label: Title
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  Data: Emergence of artemisinin-resistant malaria on the western border of Thailand: a longitudinal study.
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  Data: <searchLink fieldCode="AR" term="%22Aung+Pyae+Phyo%22">Aung Pyae Phyo</searchLink><br /><searchLink fieldCode="AR" term="%22Nkhoma%2C+Standwell%22">Nkhoma, Standwell</searchLink><br /><searchLink fieldCode="AR" term="%22Stepniewska%2C+Kasia%22">Stepniewska, Kasia</searchLink><br /><searchLink fieldCode="AR" term="%22Ashley%2C+Elizabeth+A%2E%22">Ashley, Elizabeth A.</searchLink><br /><searchLink fieldCode="AR" term="%22Nair%2C+Shalini%22">Nair, Shalini</searchLink><br /><searchLink fieldCode="AR" term="%22McGready%2C+Rose%22">McGready, Rose</searchLink><br /><searchLink fieldCode="AR" term="%22Moo%2C+Carit+ler%22">Moo, Carit ler</searchLink><br /><searchLink fieldCode="AR" term="%22Al-Saai%2C+Salma%22">Al-Saai, Salma</searchLink><br /><searchLink fieldCode="AR" term="%22Dondorp%2C+Arjen+M%2E%22">Dondorp, Arjen M.</searchLink><br /><searchLink fieldCode="AR" term="%22Lwin%2C+Khin+Maung%22">Lwin, Khin Maung</searchLink><br /><searchLink fieldCode="AR" term="%22Singhasivanon%2C+Pratap%22">Singhasivanon, Pratap</searchLink><br /><searchLink fieldCode="AR" term="%22Day%2C+Nicholas+P%2E+J%2E%22">Day, Nicholas P. J.</searchLink><br /><searchLink fieldCode="AR" term="%22White%2C+Nicholas+J%2E%22">White, Nicholas J.</searchLink><br /><searchLink fieldCode="AR" term="%22Anderson%2C+Tim+J%2E+C%2E%22">Anderson, Tim J. C.</searchLink><br /><searchLink fieldCode="AR" term="%22Nosten%2C+François%22">Nosten, François</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Lancet%22">Lancet</searchLink>. 5/26/2012, Vol. 379 Issue 9830, p1960-1966. 7p.
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  Label: Subjects
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  Data: <searchLink fieldCode="DE" term="%22Medical+research%22">Medical research</searchLink><br /><searchLink fieldCode="DE" term="%22Artemisinin%22">Artemisinin</searchLink><br /><searchLink fieldCode="DE" term="%22Parasites%22">Parasites</searchLink><br /><searchLink fieldCode="DE" term="%22Plasmodium+falciparum%22">Plasmodium falciparum</searchLink>
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  Label: Geographic Terms
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  Data: <searchLink fieldCode="DE" term="%22Myanmar%22">Myanmar</searchLink><br /><searchLink fieldCode="DE" term="%22Thailand%22">Thailand</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The article presents a study that establishes whether artemisinin resistance has spread on the Thailand-Burma border. It shows that parasite clearance half-lives lengthened from a geometric mean of 6.2 hours in 2001 to 3.7 hours in 2010. It indicates that the proportion of slow-clearing infections has increased from 0.6% in 2011 to 20% in 2010. It reveals that genetically determined artemisinin resistance in Plasmodium falciparum emerged along the border at least eight years ago.
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=76277088
RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1016/S0140-6736(12)60484-X
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      – Code: eng
        Text: English
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      Pagination:
        PageCount: 7
        StartPage: 1960
    Subjects:
      – SubjectFull: Medical research
        Type: general
      – SubjectFull: Artemisinin
        Type: general
      – SubjectFull: Parasites
        Type: general
      – SubjectFull: Plasmodium falciparum
        Type: general
      – SubjectFull: Myanmar
        Type: general
      – SubjectFull: Thailand
        Type: general
    Titles:
      – TitleFull: Emergence of artemisinin-resistant malaria on the western border of Thailand: a longitudinal study.
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            – D: 26
              M: 05
              Text: 5/26/2012
              Type: published
              Y: 2012
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