Effect of yohimbine stress on reacquisition of oxycodone seeking in rats.

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Bibliographic Details
Title:	Effect of yohimbine stress on reacquisition of oxycodone seeking in rats.
Authors:	Campbell, Amanda, Kwiatkowski, Daniela, Boughner, Emily, Leri, Francesco
Source:	Psychopharmacology. Jul2012, Vol. 222 Issue 2, p247-255. 9p.
Subjects:	Yohimbine, Oxycodone, Follow-up studies (Medicine), Psychological stress, Codeine derivatives, Narcotics, Laboratory rats
Abstract:	Rationale: Stress, a powerful precipitant of drug seeking during abstinence, may also accelerate the return to pathological patterns of intake after initial instances of drug reuse. Objective: To explore the effect of stress on a learning process underlying relapse, this study assessed the effect of yohimbine on reacquisition of oxycodone seeking. Methods: One hundred thirty-two male Sprague-Dawley rats underwent place conditioning with oxycodone (2 mg/kg, SC; ×6 days), extinction (vehicle × 6 days), and reconditioning with 0, 0.25, 2, or 5 mg/kg oxycodone (2 days). Yohimbine (0, 2.5, or 5 mg/kg, IP) was administered 30 min prior to reconditioning. Results: Pretreatment with 2.5 mg/kg yohimbine increased, while 5 mg/kg yohimbine decreased, reacquisition of oxycodone-induced place preference. A follow-up study ( n = 30) further indicated that the effect of yohimbine was specific to reacquisition. Conclusion: The observation that yohimbine can enhance reacquisition of oxycodone seeking supports the hypothesis that stress can facilitate learning processes involved in the unfolding of relapse. [ABSTRACT FROM AUTHOR]
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Database:	Psychology and Behavioral Sciences Collection

Description
Abstract:	Rationale: Stress, a powerful precipitant of drug seeking during abstinence, may also accelerate the return to pathological patterns of intake after initial instances of drug reuse. Objective: To explore the effect of stress on a learning process underlying relapse, this study assessed the effect of yohimbine on reacquisition of oxycodone seeking. Methods: One hundred thirty-two male Sprague-Dawley rats underwent place conditioning with oxycodone (2 mg/kg, SC; ×6 days), extinction (vehicle × 6 days), and reconditioning with 0, 0.25, 2, or 5 mg/kg oxycodone (2 days). Yohimbine (0, 2.5, or 5 mg/kg, IP) was administered 30 min prior to reconditioning. Results: Pretreatment with 2.5 mg/kg yohimbine increased, while 5 mg/kg yohimbine decreased, reacquisition of oxycodone-induced place preference. A follow-up study ( n = 30) further indicated that the effect of yohimbine was specific to reacquisition. Conclusion: The observation that yohimbine can enhance reacquisition of oxycodone seeking supports the hypothesis that stress can facilitate learning processes involved in the unfolding of relapse. [ABSTRACT FROM AUTHOR]
ISSN:	00333158
DOI:	10.1007/s00213-012-2640-1