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Effect of yohimbine stress on reacquisition of oxycodone seeking in rats.

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Title: Effect of yohimbine stress on reacquisition of oxycodone seeking in rats.
Authors: Campbell, Amanda, Kwiatkowski, Daniela, Boughner, Emily, Leri, Francesco
Source: Psychopharmacology. Jul2012, Vol. 222 Issue 2, p247-255. 9p.
Subjects: Yohimbine, Oxycodone, Follow-up studies (Medicine), Psychological stress, Codeine derivatives, Narcotics, Laboratory rats
Abstract: Rationale: Stress, a powerful precipitant of drug seeking during abstinence, may also accelerate the return to pathological patterns of intake after initial instances of drug reuse. Objective: To explore the effect of stress on a learning process underlying relapse, this study assessed the effect of yohimbine on reacquisition of oxycodone seeking. Methods: One hundred thirty-two male Sprague-Dawley rats underwent place conditioning with oxycodone (2 mg/kg, SC; ×6 days), extinction (vehicle × 6 days), and reconditioning with 0, 0.25, 2, or 5 mg/kg oxycodone (2 days). Yohimbine (0, 2.5, or 5 mg/kg, IP) was administered 30 min prior to reconditioning. Results: Pretreatment with 2.5 mg/kg yohimbine increased, while 5 mg/kg yohimbine decreased, reacquisition of oxycodone-induced place preference. A follow-up study ( n = 30) further indicated that the effect of yohimbine was specific to reacquisition. Conclusion: The observation that yohimbine can enhance reacquisition of oxycodone seeking supports the hypothesis that stress can facilitate learning processes involved in the unfolding of relapse. [ABSTRACT FROM AUTHOR]
Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Effect of yohimbine stress on reacquisition of oxycodone seeking in rats.
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  Data: <searchLink fieldCode="AR" term="%22Campbell%2C+Amanda%22">Campbell, Amanda</searchLink><br /><searchLink fieldCode="AR" term="%22Kwiatkowski%2C+Daniela%22">Kwiatkowski, Daniela</searchLink><br /><searchLink fieldCode="AR" term="%22Boughner%2C+Emily%22">Boughner, Emily</searchLink><br /><searchLink fieldCode="AR" term="%22Leri%2C+Francesco%22">Leri, Francesco</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Psychopharmacology%22">Psychopharmacology</searchLink>. Jul2012, Vol. 222 Issue 2, p247-255. 9p.
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  Data: <searchLink fieldCode="DE" term="%22Yohimbine%22">Yohimbine</searchLink><br /><searchLink fieldCode="DE" term="%22Oxycodone%22">Oxycodone</searchLink><br /><searchLink fieldCode="DE" term="%22Follow-up+studies+%28Medicine%29%22">Follow-up studies (Medicine)</searchLink><br /><searchLink fieldCode="DE" term="%22Psychological+stress%22">Psychological stress</searchLink><br /><searchLink fieldCode="DE" term="%22Codeine+derivatives%22">Codeine derivatives</searchLink><br /><searchLink fieldCode="DE" term="%22Narcotics%22">Narcotics</searchLink><br /><searchLink fieldCode="DE" term="%22Laboratory+rats%22">Laboratory rats</searchLink>
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  Data: Rationale: Stress, a powerful precipitant of drug seeking during abstinence, may also accelerate the return to pathological patterns of intake after initial instances of drug reuse. Objective: To explore the effect of stress on a learning process underlying relapse, this study assessed the effect of yohimbine on reacquisition of oxycodone seeking. Methods: One hundred thirty-two male Sprague-Dawley rats underwent place conditioning with oxycodone (2 mg/kg, SC; ×6 days), extinction (vehicle × 6 days), and reconditioning with 0, 0.25, 2, or 5 mg/kg oxycodone (2 days). Yohimbine (0, 2.5, or 5 mg/kg, IP) was administered 30 min prior to reconditioning. Results: Pretreatment with 2.5 mg/kg yohimbine increased, while 5 mg/kg yohimbine decreased, reacquisition of oxycodone-induced place preference. A follow-up study ( n = 30) further indicated that the effect of yohimbine was specific to reacquisition. Conclusion: The observation that yohimbine can enhance reacquisition of oxycodone seeking supports the hypothesis that stress can facilitate learning processes involved in the unfolding of relapse. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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