INFLUENCE OF ANTIOXIDANTS ON BLOOD-BRAIN BARRIER PERMEABILITY DURING ADRENALINE-INDUCED HYPERTENSION.
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| Title: | INFLUENCE OF ANTIOXIDANTS ON BLOOD-BRAIN BARRIER PERMEABILITY DURING ADRENALINE-INDUCED HYPERTENSION. |
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| Authors: | ÖZTAŞ, B., Erkin, E., Dural, E., Isbir, T. |
| Source: | International Journal of Neuroscience. 2000, Vol. 105 Issue 1-4, p27. 9p. 1 Chart, 1 Graph. |
| Subjects: | Antioxidants, Blood-brain barrier, Adrenaline, Hypertension |
| Abstract: | We have examined the effect of antioxidants (vitamin E, and selenium) on the blood brain barrier permeability during adreneline-induced acute hypertension in the female rats. The rats supplemented with nontoxic doses of sodium selenite in drinking water for three months or vitamin E was given intraperitoneally before adrenaline-induced acute hypertension. Evans-blue was used as a blood-brain barrier tracer. Mean values for Evans-blue dye were found to be 0.28 ± 0.04 μg/g tissue in control animals and 1.0 ± 0.2μg/g tissue after adrenaline-induced acute hypertension (p < .01). Rats pretreated with selenium or vitamin E also showed macroscopic leakage of Evans-blue albumin after adrenaline injection i.e., there was no significant difference in protein extravasation between untreated and treated animals (p > .5). The mean value for Evans-blue dye was found to be 1.0±0.2ug/g tissue in acute hypertension group, 0.9±0.2ug/g tissue in selenium pretreated animals and 1.0±0.2(ig/g tissue vitamin E injected animals after acute hypertension. The results show that antioxidants did not influence the blood—brain barrier breakdown during adrenaline-induced acute hypertension. [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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