Bibliographic Details
| Title: |
Anti-Inflammatory and Anti-Allergic Effect of Agaricus blazei Extract in Bone Marrow-Derived Mast Cells. |
| Authors: |
Song, Hyuk-Hwan, Chae, Hee-Sung, Oh, Sei-Ryang, Lee, Hyeong-Kyu, Chin, Young-Won |
| Source: |
American Journal of Chinese Medicine. 2012, Vol. 40 Issue 5, p1073-1084. 12p. 4 Black and White Photographs, 7 Graphs. |
| Subjects: |
Anti-inflammatory agents, Therapeutic use of plant extracts, RNA analysis, Allergens, Analysis of variance, Animal experimentation, Bone marrow, Cell migration, Cell surface antigens, Enzyme-linked immunosorbent assay, Immunodiagnosis, Mass spectrometry, Mast cells, Mice, Microbiological assay, Mushrooms, Polymerase chain reaction, Research funding, Solvents, T-test (Statistics), Western immunoblotting, Descriptive statistics |
| Abstract: |
In this study, the anti-inflammatory and anti-allergic effects of the chloroform-soluble extract of Agaricus blazei in mouse bone marrow-derived mast cells (BMMCs) were investigated. The chloroform-soluble extract inhibited IL-6 production in PMA plus A23187-stimulated BMMCs, and down-regulated the phosphorylation of Akt. In addition, this extract demonstrated inhibition of the degranulation of β-hexosaminidase and the production of IL-6, prostaglandin D2 and leukotriene C4 in PMA plus A23187-induced BMMCs. In conclusion, the chloroform-soluble extract of Agaricus blazei exerted anti-inflammatory and anti-allergic activities mediated by influencing IL-6, prostaglandin D2, leukotriene C4, and the phosphorylation of Akt. [ABSTRACT FROM AUTHOR] |
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| Database: |
Psychology and Behavioral Sciences Collection |
