View in EDS PDF Full Text

Anti-Inflammatory and Anti-Allergic Effect of Agaricus blazei Extract in Bone Marrow-Derived Mast Cells.

Saved in:
Bibliographic Details
Title: Anti-Inflammatory and Anti-Allergic Effect of Agaricus blazei Extract in Bone Marrow-Derived Mast Cells.
Authors: Song, Hyuk-Hwan, Chae, Hee-Sung, Oh, Sei-Ryang, Lee, Hyeong-Kyu, Chin, Young-Won
Source: American Journal of Chinese Medicine. 2012, Vol. 40 Issue 5, p1073-1084. 12p. 4 Black and White Photographs, 7 Graphs.
Subjects: Anti-inflammatory agents, Therapeutic use of plant extracts, RNA analysis, Allergens, Analysis of variance, Animal experimentation, Bone marrow, Cell migration, Cell surface antigens, Enzyme-linked immunosorbent assay, Immunodiagnosis, Mass spectrometry, Mast cells, Mice, Microbiological assay, Mushrooms, Polymerase chain reaction, Research funding, Solvents, T-test (Statistics), Western immunoblotting, Descriptive statistics
Abstract: In this study, the anti-inflammatory and anti-allergic effects of the chloroform-soluble extract of Agaricus blazei in mouse bone marrow-derived mast cells (BMMCs) were investigated. The chloroform-soluble extract inhibited IL-6 production in PMA plus A23187-stimulated BMMCs, and down-regulated the phosphorylation of Akt. In addition, this extract demonstrated inhibition of the degranulation of β-hexosaminidase and the production of IL-6, prostaglandin D2 and leukotriene C4 in PMA plus A23187-induced BMMCs. In conclusion, the chloroform-soluble extract of Agaricus blazei exerted anti-inflammatory and anti-allergic activities mediated by influencing IL-6, prostaglandin D2, leukotriene C4, and the phosphorylation of Akt. [ABSTRACT FROM AUTHOR]
Copyright of American Journal of Chinese Medicine is the property of World Scientific Publishing Company and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Links:
  – Type: pdflink
Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 79448837
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Anti-Inflammatory and Anti-Allergic Effect of Agaricus blazei Extract in Bone Marrow-Derived Mast Cells.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Song%2C+Hyuk-Hwan%22">Song, Hyuk-Hwan</searchLink><br /><searchLink fieldCode="AR" term="%22Chae%2C+Hee-Sung%22">Chae, Hee-Sung</searchLink><br /><searchLink fieldCode="AR" term="%22Oh%2C+Sei-Ryang%22">Oh, Sei-Ryang</searchLink><br /><searchLink fieldCode="AR" term="%22Lee%2C+Hyeong-Kyu%22">Lee, Hyeong-Kyu</searchLink><br /><searchLink fieldCode="AR" term="%22Chin%2C+Young-Won%22">Chin, Young-Won</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22American+Journal+of+Chinese+Medicine%22">American Journal of Chinese Medicine</searchLink>. 2012, Vol. 40 Issue 5, p1073-1084. 12p. 4 Black and White Photographs, 7 Graphs.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Anti-inflammatory+agents%22">Anti-inflammatory agents</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutic+use+of+plant+extracts%22">Therapeutic use of plant extracts</searchLink><br /><searchLink fieldCode="DE" term="%22RNA+analysis%22">RNA analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Allergens%22">Allergens</searchLink><br /><searchLink fieldCode="DE" term="%22Analysis+of+variance%22">Analysis of variance</searchLink><br /><searchLink fieldCode="DE" term="%22Animal+experimentation%22">Animal experimentation</searchLink><br /><searchLink fieldCode="DE" term="%22Bone+marrow%22">Bone marrow</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+migration%22">Cell migration</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+surface+antigens%22">Cell surface antigens</searchLink><br /><searchLink fieldCode="DE" term="%22Enzyme-linked+immunosorbent+assay%22">Enzyme-linked immunosorbent assay</searchLink><br /><searchLink fieldCode="DE" term="%22Immunodiagnosis%22">Immunodiagnosis</searchLink><br /><searchLink fieldCode="DE" term="%22Mass+spectrometry%22">Mass spectrometry</searchLink><br /><searchLink fieldCode="DE" term="%22Mast+cells%22">Mast cells</searchLink><br /><searchLink fieldCode="DE" term="%22Mice%22">Mice</searchLink><br /><searchLink fieldCode="DE" term="%22Microbiological+assay%22">Microbiological assay</searchLink><br /><searchLink fieldCode="DE" term="%22Mushrooms%22">Mushrooms</searchLink><br /><searchLink fieldCode="DE" term="%22Polymerase+chain+reaction%22">Polymerase chain reaction</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Solvents%22">Solvents</searchLink><br /><searchLink fieldCode="DE" term="%22T-test+%28Statistics%29%22">T-test (Statistics)</searchLink><br /><searchLink fieldCode="DE" term="%22Western+immunoblotting%22">Western immunoblotting</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: In this study, the anti-inflammatory and anti-allergic effects of the chloroform-soluble extract of Agaricus blazei in mouse bone marrow-derived mast cells (BMMCs) were investigated. The chloroform-soluble extract inhibited IL-6 production in PMA plus A23187-stimulated BMMCs, and down-regulated the phosphorylation of Akt. In addition, this extract demonstrated inhibition of the degranulation of β-hexosaminidase and the production of IL-6, prostaglandin D2 and leukotriene C4 in PMA plus A23187-induced BMMCs. In conclusion, the chloroform-soluble extract of Agaricus blazei exerted anti-inflammatory and anti-allergic activities mediated by influencing IL-6, prostaglandin D2, leukotriene C4, and the phosphorylation of Akt. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of American Journal of Chinese Medicine is the property of World Scientific Publishing Company and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=79448837
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1142/S0192415X12500796
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 12
        StartPage: 1073
    Subjects:
      – SubjectFull: Anti-inflammatory agents
        Type: general
      – SubjectFull: Therapeutic use of plant extracts
        Type: general
      – SubjectFull: RNA analysis
        Type: general
      – SubjectFull: Allergens
        Type: general
      – SubjectFull: Analysis of variance
        Type: general
      – SubjectFull: Animal experimentation
        Type: general
      – SubjectFull: Bone marrow
        Type: general
      – SubjectFull: Cell migration
        Type: general
      – SubjectFull: Cell surface antigens
        Type: general
      – SubjectFull: Enzyme-linked immunosorbent assay
        Type: general
      – SubjectFull: Immunodiagnosis
        Type: general
      – SubjectFull: Mass spectrometry
        Type: general
      – SubjectFull: Mast cells
        Type: general
      – SubjectFull: Mice
        Type: general
      – SubjectFull: Microbiological assay
        Type: general
      – SubjectFull: Mushrooms
        Type: general
      – SubjectFull: Polymerase chain reaction
        Type: general
      – SubjectFull: Research funding
        Type: general
      – SubjectFull: Solvents
        Type: general
      – SubjectFull: T-test (Statistics)
        Type: general
      – SubjectFull: Western immunoblotting
        Type: general
      – SubjectFull: Descriptive statistics
        Type: general
    Titles:
      – TitleFull: Anti-Inflammatory and Anti-Allergic Effect of Agaricus blazei Extract in Bone Marrow-Derived Mast Cells.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Song, Hyuk-Hwan
      – PersonEntity:
          Name:
            NameFull: Chae, Hee-Sung
      – PersonEntity:
          Name:
            NameFull: Oh, Sei-Ryang
      – PersonEntity:
          Name:
            NameFull: Lee, Hyeong-Kyu
      – PersonEntity:
          Name:
            NameFull: Chin, Young-Won
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 10
              Text: 2012
              Type: published
              Y: 2012
          Identifiers:
            – Type: issn-print
              Value: 0192415X
          Numbering:
            – Type: volume
              Value: 40
            – Type: issue
              Value: 5
          Titles:
            – TitleFull: American Journal of Chinese Medicine
              Type: main
ResultId 1