Saliva cortisol and male depressive syndrome in a community study. The Sudurnesjamenn study.
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| Title: | Saliva cortisol and male depressive syndrome in a community study. The Sudurnesjamenn study. |
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| Authors: | Sigurdsson, Bjarni (AUTHOR), Palsson, Sigurdur Pall (AUTHOR), Johannsson, Magnus (AUTHOR), Olafsdottir, Maria (AUTHOR), Aevarsson, Olafur (AUTHOR) |
| Source: | Nordic Journal of Psychiatry. Jun2013, Vol. 67 Issue 3, p145-152. 8p. 2 Charts, 1 Graph. |
| Subjects: | Hydrocortisone, Mental depression, Hypothalamic-pituitary-adrenal axis, Mental health |
| Geographic Terms: | Montgomery (Ala.) |
| Abstract: | Background: The degree and direction of hypothalamic-pituitary-adrenal (HPA) dysfunction to male mental health is unclear. Aims: The aim of the study was to investigate the relationship between cortisol and male mental health. Methods: In this community study, 534 males were screened, using the Beck Depression Inventory (BDI), Gotland Male Depression Scale (GMDS) and a general health questionnaire. Those with signs of depression ( n = 65) and controls ( n = 69) were evaluated in a psychiatric examination according to the DSM-IV criteria for depressive disorder (DD). In a sub-sample ( n = 51) saliva cortisol was measured five times on a single day. Results: Evening cortisol was significantly higher in untreated individuals with DD. Significantly higher evening cortisol (at 22 h) correlated also with a history of physical disorder, a history of any mental disorder and MADRS score ≥ 20 (Montgomery-Åsberg Depression Rating Scale). High cortisol, measured as AUC (area under curve), correlated with a high MADRS score but not with any other health variable tested. Morning cortisol did not correlate with any health variable; however, cortisol awakening response (CAR) could not be investigated. The BDI and GMDS scores did not correlate with cortisol measurements. Conclusion: Evening saliva cortisol measurement seems most informative, as it correlates with male depressive syndrome in our study but replications with larger studies are needed. [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | Background: The degree and direction of hypothalamic-pituitary-adrenal (HPA) dysfunction to male mental health is unclear. Aims: The aim of the study was to investigate the relationship between cortisol and male mental health. Methods: In this community study, 534 males were screened, using the Beck Depression Inventory (BDI), Gotland Male Depression Scale (GMDS) and a general health questionnaire. Those with signs of depression ( n = 65) and controls ( n = 69) were evaluated in a psychiatric examination according to the DSM-IV criteria for depressive disorder (DD). In a sub-sample ( n = 51) saliva cortisol was measured five times on a single day. Results: Evening cortisol was significantly higher in untreated individuals with DD. Significantly higher evening cortisol (at 22 h) correlated also with a history of physical disorder, a history of any mental disorder and MADRS score ≥ 20 (Montgomery-Åsberg Depression Rating Scale). High cortisol, measured as AUC (area under curve), correlated with a high MADRS score but not with any other health variable tested. Morning cortisol did not correlate with any health variable; however, cortisol awakening response (CAR) could not be investigated. The BDI and GMDS scores did not correlate with cortisol measurements. Conclusion: Evening saliva cortisol measurement seems most informative, as it correlates with male depressive syndrome in our study but replications with larger studies are needed. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 08039488 |
| DOI: | 10.3109/08039488.2012.704069 |
