Bibliographic Details
| Title: |
Altered IMPA2 gene expression and calcium homeostasis in bipolar disorder. |
| Authors: |
Yoon, I-S, Li, P P, Siu, K-P, Kennedy, J L, Cooke, R G, Parikh, S V, Warsh, J J |
| Source: |
Molecular Psychiatry. 2001, Vol. 6 Issue 6, p678. 6p. |
| Subjects: |
Gene expression, Homeostasis, Calcium, Genetic transduction |
| Abstract: |
Reduced inositol monophosphatase (IMPase) activity and elevated basal intracellular calcium levels ([Ca[SUP2+]][SUBB]) have been reported in B lymphoblast cell lines (BLCLs) from bipolar I affective disorder (BD-I) patients, which may reflect cellular endophenotypes of this disorder. As the PI cycle couples to intracellular Ca[SUP2+] mobilization, these two putative endophenotypes may be related. Using an RT-PCR assay, mRNA levels were estimated for IMPA1 and 2 genes encoding human IMPase 1 and 2, respectively, in BLCLs phenotyped on [Ca[SUP2+]][SUBB], from patients with a DSM-IV diagnosis of BD-I (n = 12 per phenotype) and from age- and sex-matched healthy subjects (n = 12). IMPA2 mRNA levels were significantly lower in BLCLs from male BD-I patients with high [Ca[SUP2+]][SUBB](n = 6) compared with healthy male subjects (n = 5) (-52%, P = 0.013), male BD-I patients with normal BLCL [Ca[SUP2+]][SUBB] (n = 8) (-42%, P = 0.003) and female BD-I patients with high [Ca[SUP2+]][SUBB] (n = 6) (-59%, P = 0.0004). A significant negative correlation was observed between IMPA2 mRNA levels and [Ca[SUP2+]][SUBB] (in BLCLs from male (P = 0.046), but not female BD-I patients. Sex-dependent differences were also evident in postmortem temporal cortex IMPA2 mRNA levels which, in contrast to BLCLs, were significantly higher in male BD-I subjects compared with male controls (P = 0.025, n = 4/group). Collectively, these observations suggest a potential sex-dependent link between abnormalities in IMPA2 expression and calcium homeostasis in the pathophysiology of BD. [ABSTRACT FROM AUTHOR] |
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| Database: |
Psychology and Behavioral Sciences Collection |
