Altered IMPA2 gene expression and calcium homeostasis in bipolar disorder.
Saved in:
| Title: | Altered IMPA2 gene expression and calcium homeostasis in bipolar disorder. |
|---|---|
| Authors: | Yoon, I-S, Li, P P, Siu, K-P, Kennedy, J L, Cooke, R G, Parikh, S V, Warsh, J J |
| Source: | Molecular Psychiatry. 2001, Vol. 6 Issue 6, p678. 6p. |
| Subjects: | Gene expression, Homeostasis, Calcium, Genetic transduction |
| Abstract: | Reduced inositol monophosphatase (IMPase) activity and elevated basal intracellular calcium levels ([Ca[SUP2+]][SUBB]) have been reported in B lymphoblast cell lines (BLCLs) from bipolar I affective disorder (BD-I) patients, which may reflect cellular endophenotypes of this disorder. As the PI cycle couples to intracellular Ca[SUP2+] mobilization, these two putative endophenotypes may be related. Using an RT-PCR assay, mRNA levels were estimated for IMPA1 and 2 genes encoding human IMPase 1 and 2, respectively, in BLCLs phenotyped on [Ca[SUP2+]][SUBB], from patients with a DSM-IV diagnosis of BD-I (n = 12 per phenotype) and from age- and sex-matched healthy subjects (n = 12). IMPA2 mRNA levels were significantly lower in BLCLs from male BD-I patients with high [Ca[SUP2+]][SUBB](n = 6) compared with healthy male subjects (n = 5) (-52%, P = 0.013), male BD-I patients with normal BLCL [Ca[SUP2+]][SUBB] (n = 8) (-42%, P = 0.003) and female BD-I patients with high [Ca[SUP2+]][SUBB] (n = 6) (-59%, P = 0.0004). A significant negative correlation was observed between IMPA2 mRNA levels and [Ca[SUP2+]][SUBB] (in BLCLs from male (P = 0.046), but not female BD-I patients. Sex-dependent differences were also evident in postmortem temporal cortex IMPA2 mRNA levels which, in contrast to BLCLs, were significantly higher in male BD-I subjects compared with male controls (P = 0.025, n = 4/group). Collectively, these observations suggest a potential sex-dependent link between abnormalities in IMPA2 expression and calcium homeostasis in the pathophysiology of BD. [ABSTRACT FROM AUTHOR] |
| Copyright of Molecular Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
|---|---|
| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 8884265 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Altered IMPA2 gene expression and calcium homeostasis in bipolar disorder. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Yoon%2C+I-S%22">Yoon, I-S</searchLink><br /><searchLink fieldCode="AR" term="%22Li%2C+P+P%22">Li, P P</searchLink><br /><searchLink fieldCode="AR" term="%22Siu%2C+K-P%22">Siu, K-P</searchLink><br /><searchLink fieldCode="AR" term="%22Kennedy%2C+J+L%22">Kennedy, J L</searchLink><br /><searchLink fieldCode="AR" term="%22Cooke%2C+R+G%22">Cooke, R G</searchLink><br /><searchLink fieldCode="AR" term="%22Parikh%2C+S+V%22">Parikh, S V</searchLink><br /><searchLink fieldCode="AR" term="%22Warsh%2C+J+J%22">Warsh, J J</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Molecular+Psychiatry%22">Molecular Psychiatry</searchLink>. 2001, Vol. 6 Issue 6, p678. 6p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Gene+expression%22">Gene expression</searchLink><br /><searchLink fieldCode="DE" term="%22Homeostasis%22">Homeostasis</searchLink><br /><searchLink fieldCode="DE" term="%22Calcium%22">Calcium</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+transduction%22">Genetic transduction</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Reduced inositol monophosphatase (IMPase) activity and elevated basal intracellular calcium levels ([Ca[SUP2+]][SUBB]) have been reported in B lymphoblast cell lines (BLCLs) from bipolar I affective disorder (BD-I) patients, which may reflect cellular endophenotypes of this disorder. As the PI cycle couples to intracellular Ca[SUP2+] mobilization, these two putative endophenotypes may be related. Using an RT-PCR assay, mRNA levels were estimated for IMPA1 and 2 genes encoding human IMPase 1 and 2, respectively, in BLCLs phenotyped on [Ca[SUP2+]][SUBB], from patients with a DSM-IV diagnosis of BD-I (n = 12 per phenotype) and from age- and sex-matched healthy subjects (n = 12). IMPA2 mRNA levels were significantly lower in BLCLs from male BD-I patients with high [Ca[SUP2+]][SUBB](n = 6) compared with healthy male subjects (n = 5) (-52%, P = 0.013), male BD-I patients with normal BLCL [Ca[SUP2+]][SUBB] (n = 8) (-42%, P = 0.003) and female BD-I patients with high [Ca[SUP2+]][SUBB] (n = 6) (-59%, P = 0.0004). A significant negative correlation was observed between IMPA2 mRNA levels and [Ca[SUP2+]][SUBB] (in BLCLs from male (P = 0.046), but not female BD-I patients. Sex-dependent differences were also evident in postmortem temporal cortex IMPA2 mRNA levels which, in contrast to BLCLs, were significantly higher in male BD-I subjects compared with male controls (P = 0.025, n = 4/group). Collectively, these observations suggest a potential sex-dependent link between abnormalities in IMPA2 expression and calcium homeostasis in the pathophysiology of BD. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Molecular Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=8884265 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/sj.mp.4000901 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 6 StartPage: 678 Subjects: – SubjectFull: Gene expression Type: general – SubjectFull: Homeostasis Type: general – SubjectFull: Calcium Type: general – SubjectFull: Genetic transduction Type: general Titles: – TitleFull: Altered IMPA2 gene expression and calcium homeostasis in bipolar disorder. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Yoon, I-S – PersonEntity: Name: NameFull: Li, P P – PersonEntity: Name: NameFull: Siu, K-P – PersonEntity: Name: NameFull: Kennedy, J L – PersonEntity: Name: NameFull: Cooke, R G – PersonEntity: Name: NameFull: Parikh, S V – PersonEntity: Name: NameFull: Warsh, J J IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 11 Text: 2001 Type: published Y: 2001 Identifiers: – Type: issn-print Value: 13594184 Numbering: – Type: volume Value: 6 – Type: issue Value: 6 Titles: – TitleFull: Molecular Psychiatry Type: main |
| ResultId | 1 |
