Stability and Change of Genetic and Environmental Effects on the Common Liability to Alcohol, Tobacco, and Cannabis DSM-IV Dependence Symptoms.

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Bibliographic Details
Title:	Stability and Change of Genetic and Environmental Effects on the Common Liability to Alcohol, Tobacco, and Cannabis DSM-IV Dependence Symptoms.
Authors:	Palmer, R., Young, S., Corley, R., Hopfer, C., Stallings, M., Hewitt, J.
Source:	Behavior Genetics. Sep2013, Vol. 43 Issue 5, p374-385. 12p. 2 Diagrams, 5 Charts.
Subjects:	Alcohol, Tobacco, Cannabis (Genus), Symptoms, Adults, Gender differences (Psychology), Longitudinal method, Heritability, Physiology
Abstract:	This study investigated the stability of genetic and environmental effects on the common liability to alcohol, tobacco, and cannabis dependence across adolescence and young adulthood. DSM-IV symptom counts from 2,361 adolescents were obtained using a structured diagnostic interview. Several sex-limited longitudinal common pathway models were used to examine gender differences in the magnitude of additive genetic (A), shared environment, and non-shared environmental effects over time. Model fitting indicated limited gender differences. Among older adolescents (i.e., age >14), the heritability of the latent trait was estimated at 0.43 (0.05, 0.94) during the first wave and 0.63 (0.21, 0.83) during the second wave of assessment. A common genetic factor could account for genetic influences at both assessments, as well as the majority of the stability of SAV over time [rA = 1.00 (0.55, 1.00)]. These results suggest that early genetic factors continue to play a key role at later developmental stages. [ABSTRACT FROM AUTHOR]
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Database:	Psychology and Behavioral Sciences Collection

Description
Abstract:	This study investigated the stability of genetic and environmental effects on the common liability to alcohol, tobacco, and cannabis dependence across adolescence and young adulthood. DSM-IV symptom counts from 2,361 adolescents were obtained using a structured diagnostic interview. Several sex-limited longitudinal common pathway models were used to examine gender differences in the magnitude of additive genetic (A), shared environment, and non-shared environmental effects over time. Model fitting indicated limited gender differences. Among older adolescents (i.e., age >14), the heritability of the latent trait was estimated at 0.43 (0.05, 0.94) during the first wave and 0.63 (0.21, 0.83) during the second wave of assessment. A common genetic factor could account for genetic influences at both assessments, as well as the majority of the stability of SAV over time [rA = 1.00 (0.55, 1.00)]. These results suggest that early genetic factors continue to play a key role at later developmental stages. [ABSTRACT FROM AUTHOR]
ISSN:	00018244
DOI:	10.1007/s10519-013-9599-5