Bibliographic Details
| Title: |
The causes and consequences of genetic heterogeneity in cancer evolution. |
| Authors: |
Burrell, Rebecca A., McGranahan, Nicholas, Bartek, Jiri, Swanton, Charles |
| Source: |
Nature. 9/19/2013, Vol. 501 Issue 7467, p338-345. 8p. 1 Diagram, 1 Chart. |
| Subjects: |
Genes, Diversity & Accommodation (Book), Tumors, Cancer, Plethora (Pathology), Evolutionary theories |
| Abstract: |
Recent studies have revealed extensive genetic diversity both between and within tumours. This heterogeneity affects key cancer pathways, driving phenotypic variation, and poses a significant challenge to personalized cancer medicine. A major cause of genetic heterogeneity in cancer is genomic instability. This instability leads to an increased mutation rate and can shape the evolution of the cancer genome through a plethora of mechanisms. By understanding these mechanisms we can gain insight into the common pathways of tumour evolution that could support the development of future therapeutic strategies. [ABSTRACT FROM AUTHOR] |
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| Database: |
Psychology and Behavioral Sciences Collection |
